New mosquito automated liquid handling system hastens research into proteinbased therapeutics

first_imgresearch into protein-based therapeutics is on the increase as they are more easily assimilated into the body’s own defence system. We are pleased that we can offer systems like the mosquito and other screening technologies that will help develop the next generation of biopharmaceuticals to teams like Professor Parker’s with a view to minimizing the impacts of diseases and ailments that affect our society. May 2 2018AXT have recently completed the installation of an automated liquid handling system at the Victoria University of Wellington in New Zealand. The TTP Labtech mosquito will be used by researchers to probe the atomic structure of proteins and will help accelerate their research by automatically preparing hundreds of samples. The mosquito has become a valuable instrument in our research workflow. Important biological processes are mediated by proteins. Studying protein structures helps us to understand how proteins function. This understanding will help us to control and engineer desired proteins that can be used as treatments to address critical global problems. The mosquito is the perfect partner for protein crystallographers as it combines speed, accuracy and high precision pipetting, all in a user-friendly package. Furthermore, the positive displacement pipette technology ensures repeatable liquid dispensing down to the nanoliter level that maximize the usability of valuable reagents. Combining this with single use disposable pipette tips prevents the possibility of cross-contamination ensuring the purity and accuracy of each and every formulation prepared.Related StoriesDrug discovery research at University of Nottingham supported by TTP LabtechFirst AXT Biospecimen Storage System Installed in the Southern Hemisphere at Griffith UniversityAXT to introduce LUMICKS’ product lines for dynamic single-molecule analysis to AustraliaThe highly automated and high throughput nature of the mosquito liquid handling system will allow the researchers to prepare the vast numbers of samples required for accurate screening experiments. These numbers are typically in the hundreds if not thousands and are necessary to help identify the optimal conditions for preparing the best crystals. Use of the mosquito accelerates this process bringing it down from days or even months.Professor Emily Parker from the Ferrier Research Institute at the Victoria University of Wellington commented: Richard Trett, Managing Director at AXT also said:center_img The mosquito from TTP Labtech is part of AXT’s protein-based product portfolio that also includes X-ray-based protein crystallography systems from Rigaku Oxford Diffraction and protein characterization tools from Unchained Labs. Some of the team at the Ferrier Research Institute and their new mosquito automated liquid handling system from TTP Labtech. Source:http://www.axt.com.au/next-generation-protein-based-therapeutics/last_img read more

Even warriors benefit from making friends

first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country Click to view the privacy policy. Required fields are indicated by an asterisk (*) Imagine you’re a Yanomamö man, growing crops and hunting in the Amazon rainforest of southern Venezuela and northern Brazil. Someone from your village has been murdered, and you’re organizing a raiding party to do a revenge killing. Whom do you choose to fight alongside you?Your brothers, guessed cultural anthropologist Shane Macfarlan of the University of Utah in Salt Lake City. Based on evolutionary theory and the importance of patrilineages in the Yanomamö’s social structure, Macfarlan assumed that a group of Yanomamö warriors, or unokai, was a literal band of brothers—a group of close male relatives who had lived in the same community their whole lives.Macfarlan checked that assumption with data gathered back in the 1960s and 1970s by Napoleon Chagnon, an extremely divisive figure in anthropology who nevertheless amassed a valuable database on Yanomamö genealogy and warfare. Macfarlan discovered to his surprise that most co-unokais, or men who participated in the same killing, weren’t brothers. At best, they were cousins. But most were related by marriage: Seventy percent of married unokais had a wife directly related to one of their co-unokais. Emailcenter_img The paper, published online today in the Proceedings of the National Academy of Sciences, offers a twist on Chagnon’s original ideas about how being a warrior boosts men’s fitness, and fits current notions that war is a mode of cooperation. “Humans are able to cooperate even in costly settings like warfare beyond the residential community and beyond kin,” says Sarah Mathew, an anthropologist at Arizona State University (ASU), Tempe, who studies the evolution of human cooperation. That’s “a real exceptional feature of Homo sapiens,” notes Kim Hill, a human behavioral ecologist also at ASU who has studied small-scale tribal societies in South America.During 3 decades of living with and studying the Yanomamö, Chagnon, now at the University of Missouri, Columbia, gathered reams of information about their marriages, wars, alliances, and other relationships. But some anthropologists said his 1968 ethnography, Yanomamö: The Fierce People, exploited the tribe by breaking their taboo on using the names of the dead; others argued that its emphasis on violent encounters helped governments justify invasions of Yanomamö territory. Chagnon also faced criticism for infractions such as giving gifts, including machetes, to his closest Yanomamö associates, and thus distorting the social structure he aimed to analyze. In 2000, journalist Patrick Tierney even accused him of worsening a measles epidemic among the Yanomamö as part of a biomedical experiment. The American Anthropological Association, however, cleared Chagnon of that and most other charges in 2001 and rescinded their remaining criticisms in 2005.For his part, Macfarlan calls Chagnon’s data “one of the most unique data sets in the world,” capturing the Yanomamö at a time before outside influences had altered their way of life. Listening to Chagnon’s extensive recorded interviews with his Yanomamö informants assuaged any doubts he had about data collection, Macfarlan says.Macfarlan believes that his new view of how warriors benefited from becoming unokai could explain one of Chagnon’s most controversial findings. In 1988, Chagnon reported in Science that unokais of every age had more wives and children than their nonunokai counterparts. He hypothesized that being a warrior gave men high social standing and so made them more attractive as marriage partners and fathers. His suggestion that warfare and violence are “adaptive” behaviors that help drive human evolution quickly attracted fiery criticism.Some of those ideas are no longer so startling. But in contrast to Chagnon’s focus on warriors’ reputations, Macfarlan found that the key advantage held by unokais was that they “are plugged into this social scene” that allows them to make strong alliances outside of their immediate paternal family, often in different villages. That gives them access to their friends’ female relatives as potential wives. They are “getting the resources and marriage opportunities of [their] allies,” not their defeated enemies, Macfarlan says.The study shows that for the Yanomamö and possibly other small-scale societies, “warfare is about cooperation,” agrees Stephen Beckerman, an anthropologist and professor emeritus at Pennsylvania State University, University Park. He plans a similar analysis of alliances among the Waorani, another small-scale society in the Amazon with a tradition of waging war.Macfarlan acknowledges that Chagnon’s data don’t rule out the possibility that Yanomamö warriors formed raiding parties with men who were already their in-laws, confirming existing bonds rather than forging new ones. In fact, Hill notes, men in many small-scale societies often prefer to ally with their brothers-in-law because by definition these men aren’t competing for access to the same women.Although Hill doesn’t expect the new paper to sway any of Chagnon’s most committed critics, he says it represents “a more subtle and nuanced view of human society” than the anthropologist has articulated in the past. “It’s nice to see Chagnon reanalyzing some of his data 30 or 40 years later and coming up with a slightly different view of things.” Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwelast_img read more

Batfilled tree may have been ground zero for the Ebola epidemic

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Click to view the privacy policy. Required fields are indicated by an asterisk (*) Sign up for our daily newsletter Get more great content like this delivered right to you! Country Soon after the outbreak was identified as Ebola in March 2014, wildlife epidemiologist Fabian Leendertz of the Robert Koch Institute in Berlin went to southeastern Guinea to look for signs of an outbreak in wildlife. Leendertz, with three more German veterinarians and eight Guinean biosurvey experts from the nonprofit Wild Chimpanzee Foundation, spent 4 weeks in the region, capturing bats from four sites and surveying two protected forest areas.The researchers found no evidence that wild animals were dying of Ebola, they report in a paper published online today in EMBO Molecular Medicine. The populations of chimpanzees, duikers, and other large mammals were at about the same levels they had been in the previous surveys in the region, conducted in 2010 and 2011—“good news for conservation,” Leendertz says. They also found no direct evidence of Ebola virus infections in any of the 169 bats (from at least 13 species) that they captured and tested. But their visit to Meliandou yielded intriguing clues.There, they found a large tree stump near a well-traveled path to a small river where villagers washed their clothes. The hollow tree was only 50 meters from the house where the toddler lived; children used to play in it, residents told the researchers. But on 24 March, the tree had burned, Leendertz says—and all that was left were the stump, fallen branches, and ashes. (It’s not clear whether someone set it on fire deliberately because of the Ebola outbreak. “There are different stories about why it burned,”Leendertz says.)When the tree started burning, there was a “rain of bats,” villagers told Leendertz—a small, smelly species with a long tail locally called lolibelo and sometimes “mice that can fly.” In the ash surrounding the tree, the researchers found DNA fragments that match the Angolan free-tailed bat Mops condylurus, an insect-eating species that is widespread across Central and West Africa and that fits the villagers’ description. Other studies have found that the species can survive experimental infections with Ebola.The toddler could have picked up the virus while playing in the tree, Leendertz says; he might have caught and played with an infected bat or ingested a small quantity of infected bat droppings. “There must have been thousands of bats in there. That is more exposure than you can get by hunting individual bats,” Leendertz notes. He’s disappointed, but not particularly surprised, that they found no infected bats in their samples. “The virus must be extremely rare” in bat populations, he says. Because bats are hunted so much, if the Ebola virus were widespread, “we’d see infections all the time.”Peter Walsh of the University of Cambridge in the United Kingdom, who studies Ebola in wildlife in Central Africa, says the evidence linking the outbreak to the bat tree is frustratingly indirect. “It is suggestive, but it certainly doesn’t rise to a ‘smoking gun’ level,” he says. The wildlife surveys were too small to convincingly rule out an outbreak in wild animals, he adds.Leendertz agrees, but notes that there is little intact forest around Meliandou, which would limit contact with wildlife. And the fact that children and women, rather than hunters, were the first people known to be infected also suggests that eating bush meat or contact with forest-dwelling animals is relatively unlikely to have sparked this outbreak. He and his colleagues are continuing to sample bats and other wildlife in the region—most recently from Ivory Coast, close to the Guinean border. In Guinea, he says, surveys aren’t possible at the moment. With the Ebola epidemic still raging there, “people are very suspicious,” he says—especially of anyone who wants to capture bats.*The Ebola Files: Given the current Ebola outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicinehave made a collection of research and news articles on the viral disease freely available to researchers and the general public.center_img Email The source of the ongoing Ebola epidemic in West Africa may have been a hollow tree where children played—and bats roosted. In a visit to Meliandou, the Guinean village where the outbreak apparently started, researchers learned of the tree and linked it to one of the outbreak’s first victims. But, in a frustrating twist, the tree had burned to a stump just before they arrived, thwarting their search for evidence that might confirm the scenario.A year ago, a toddler in Meliandou died of a mysterious disease; soon, his sister, mother, and  grandmother were infected as well. As far as epidemiologists can tell, the family members were the first people to die in West Africa’s Ebola epidemic, which according to the latest statistics from the World Health Organization has now sickened more than 20,000 people and killed at least 7842. But how the toddler caught the virus has been a puzzle. Before the current outbreak, there was only a single known human case of Ebola in West Africa. Human Ebola outbreaks elsewhere have been linked to outbreaks in wildlife—including duikers (small antelope), gorillas, and chimpanzees—or traced to hunters who butchered animals found dead in the forest. No one knows which animals provide the natural reservoir for Ebola, but bats are leading suspects. Several types of bats can survive experimental infection with the virus, and researchers have found Ebola virus RNA in at least three species of fruit bats. That made the animals—commonly hunted and eaten in Guinea—a top contender as the source of the outbreak.last_img read more

US House takes its whacks at planning for 2020 census and at

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe That approach could be penny wise and pound foolish, however. The reduced funding levels, if adopted by the Senate, would make it difficult for the agency to properly test proposed changes to the next census that they say could save $5 billion. Those changes include making the census available online and using existing government records to provide answers to some of the questions. The goal is to send fewer workers out into the field to track down those who haven’t completed their forms, the biggest single cost of any census.Census Bureau Director John Thompson has told Congress he hopes to carry out the 2020 census for no more than the 2010 census cost, on a per-household basis. But census officials say they won’t adopt any changes that sacrifice the quality of the enumeration.The 2-day debate on the Commerce, Justice, Science (CJS) Appropriations spending bill  also gave Representative Ted Poe (R–TX) an opportunity to win support for his long-running assault on the American Community Survey (ACS), a monthly questionnaire that goes out to 3.5 million people and supplements the decennial census. Answering the survey is now mandatory, a provision meant to ensure that the data it provides paints an accurate picture of everything from the nation’s commuting characteristics to residential energy usage. But Poe believes that the ACS asks many “intrusive and personal questions” and that the people chosen to participate should be able to ignore those that offend them.Last month he reintroduced a bill (H.R. 2255) that would make the ACS voluntary except for gathering information on names and addresses. Since most programmatic, or authorization, bills are never enacted, Poe chose something that eventually Congress must pass—an annual spending bill—and tweaked his legislation to fit its narrower scope. Specifically, his amendment would prohibit the Census Bureau from spending money to compel people to respond.As it happens, the bureau has just begun a pilot study of what it hopes could be a kinder, gentler ACS. It is testing modifications to messages in survey mailings with the goal of addressing critics, like Poe, who feel that it is being heavy-handed. (Nonrespondents are subject to prosecution and a fine, although no money has ever been collected.)“This Amendment defunds enforcement of the criminal penalty of the survey,” Poe explained in a statement after his amendment was adopted by a voice vote. “The ACS is an unnecessary waste and an abuse of government power with no constitutional authority.”On 10 June the Senate CJS subcommittee is scheduled to mark up its version of the 2016 spending bill, the next step on its journey. And there are outspoken critics of the ACS in that body as well, including Senator James Lankford (R–OK). So if and when the bill moves to the Senate floor, no one will be surprised if a version of Poe’s amendment is introduced. Republicans in the U.S. House of Representatives have again shown their low regard for the Census Bureau, voting to use it as a bank to fund other federal agencies and telling people they don’t have to fill out a survey that allows the government to track the country’s changing demographics.The moves came in a series of amendments to a 2016 spending bill for the Department of Commerce, home of the Census Bureau, and several other agencies that passed last night on a mostly party line vote of 242 to 183. House members took a total of $121 million from what officials say they will need in 2016 to prepare for the 2020 census and gave it to other federal agencies. (Terri Ann Lowenthal’s The Census Project Blog provides a blow-by-blow account.)Last month, the House appropriations committee cut the agency’s requested 2016 budget for census-related activities by $374 million. After this week that amount has grown to nearly half a billion dollars less than the $1.2 billion the administration is seeking for those activities. The swaps conform to the Republican leadership’s dictate that any proposed spending increases be revenue-neutral, that is, that legislators find the money from another agency. And the Census Bureau’s proposed 38% increase for 2016 makes it a popular target. Click to view the privacy policy. Required fields are indicated by an asterisk (*)center_img Email Sign up for our daily newsletter Get more great content like this delivered right to you! Countrylast_img read more

Everglades Foundation launches 10 million prize to clean up toxic algae blooms

first_imgAlgae blooms are typically caused by agricultural runoff or sewage that dumps large amounts of nitrogen and phosphorus into the water. The removal of phosphorus and algae is a long and expensive process. The Barley prize, named after the co-founder of the foundation, aims to find a better and cheaper way.The competition officially opens today, and in 6 months the foundation plans to award a total of $35,000 to a handful of teams with good ideas. The remaining competitors will then be asked to demonstrate how their technology performs under specific conditions. The foundation will choose one team to scale up the technology and receive the grand prize. “These type of initiatives are really important,” says Tim Davis, an ecologist at the National Oceanic and Atmospheric Administration Great Lakes Environmental Research Laboratory in Ann Arbor, Michigan. “And being able to have funding to help implement strategies and innovations that will reduce [phosphorous] is a key component to reducing harmful algal blooms and bringing lakes back to a healthy state.”Nitrogen is another culprit in toxic algal blooms, Davis says, “but we don’t have the same amount of data and models for nitrogen.” He calls reducing phosphorous “a great first step” toward finding a comprehensive solution to this serious problem. Sign up for our daily newsletter Get more great content like this delivered right to you! Country Removing the phosphorus that causes toxic algal blooms in bodies of water around the world is a huge challenge for conservationists. The Everglades Foundation hopes that a $10 million prize will spur the development of cost-effective technology that can lick the problem.Today, the Palmetto Bay, Florida–based foundation officially launched the George Barley Water Prize, with the goal of removing phosphorus from the water at a cost that doesn’t exceed $120 a kilogram. “It’s going to be hard to get there, but we trust that someone somewhere has the capabilities,” says Melodie Naja, chief scientist at the foundation.The need is pressing. In May, Lake Okeechobee—the largest freshwater lake in the state of Florida—was hit with an algae bloom that extended across 33 miles. Unusually heavy rains forced water districts to drain other lakes and rivers earlier than usual to avoid flooding. That action funneled warm, nitrogen-rich water through the St. Lucie Canal into Lake Okeechobee. Click to view the privacy policy. Required fields are indicated by an asterisk (*)center_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Emaillast_img read more

Meet the only animal known to pump blood with its guts

first_imgMeet the only animal known to pump blood with its guts By Katie LanginJul. 10, 2017 , 12:00 PM High school biology classes teach us that the circulatory system pumps blood and the digestive system pumps food. But sea spiders (pictured) apparently skipped that lesson: They pump blood using their guts. Researchers discovered the remarkable physiological strategy after injecting dye into sea spiders—common inhabitants of the world’s oceans named for their resemblance to land-based spiders—and watching the flow of blood. They noticed that the animals’ hearts were beating weakly. But the digestive system—which is unusually extensive in sea spiders, running down each leg—was contracting in waves, moving food in the gut as well as blood in the surrounding hemocoel cavity, the spider equivalent of veins and arteries. Additional experiments using 12 sea spider species from Antarctica and the United States confirmed that gut contractions propel the flow of blood and oxygen in this group of marine-dwelling arthropods, the team reports today in Current Biology. It’s not clear exactly why the digestive system does the job, but it could save energy having gut contractions move food and blood. Sea spiders also have an unusual need to move oxygen from their extremities to the core of their bodies because they lack gills, and most oxygen is taken up by diffusion through the surface of their long legs. It’s the first time a blood-pumping system like this has been found in nature, but the authors suspect that other animals may do something similar.last_img read more

Mercurys snakes get formal names

first_img By Nola Taylor ReddApr. 9, 2018 , 12:20 PM When NASA’s Mercury Surface, Space Environment, Geochemistry, and Ranging spacecraft made its first flyby of Mercury in 2008, astronomers spotted strange deposits: blankets of material ranging from tens to thousands of kilometers wide whose color led researchers to informally dub them “red spots.” To date, scientists have cataloged more than 150 of these objects—and now, the International Astronomical Union has given them formal names.All of the new monikers contain “facula,” which means “bright spot,” because they are brighter than the background terrain, as well as the word “snake” in one of Earth’s various languages. They take their serpentine name not from their appearance, but because the Roman god Mercury often appears with snakes on his staff.Four of the seven newly named features lie in the Caloris basin, shown above, where faculae take names from African languages of the Somalian, Igbo (of southeastern Nigeria), Arabic, and Afrikaans. The remaining features—announced Friday—contain the Irish, Welsh, and Basque words for snakes. Spread across the planet, the faculae have been linked to billions of years of explosive volcanism in Mercury’s past. Back then, rising, volatile-rich magma caused a more violent explosion than molten rock alone would have experienced, suggesting that Mercury’s interior wasn’t as dry as once thought. Mercury’s ‘snakes’ get formal namescenter_img Carnegie Institution of Washington/Johns Hopkins University Applied Physics Laboratory/NASA last_img read more

Podcast debating the start date of our current geological age and fighting

first_img We now live in the Meghalayan age—the last age of the Holocene epoch. Did you get the memo? A July decision by the International Commission on Stratigraphy, which is responsible for naming geological time periods, divided the Holocene into three ages: the Greenlandian, the Northgrippian, and the Meghalayan. The one we live in—the Meghalayan age (pronounced “megalion”)—is pegged to a global drought thought to have happened some 4200 years ago. But many critics question the timing of this latest age and the global expanse of the drought. Staff writer Paul Voosen talks with host Sarah Crespi about the evidence for and against the global drought—and what it means if it’s wrong.Sarah also talks to staff writer Kelly Servick about her feature story on what happens when biocontrol goes out of control. Here’s the setup: U.S. Department of Agriculture researchers wanted to know whether brown marmorated stink bugs that have invaded the United States could be controlled—aka killed—by importing their natural predators, samurai wasps, from Asia. But before they could find out, the wasps showed up anyway. Kelly discusses how using one species to combat another can go wrong—or right—and what happens when the situation outruns regulators.This week’s episode was edited by Podigy.Download a transcript of this episode (PDF)Listen to previous podcasts.[Image: Melissa McMasters/Flickr; Music: Jeffrey Cook] Melissa McMasters/Flickr last_img read more

Googles DeepMind aces protein folding

first_imgComplex of bacteria-infecting viral proteins modeled in CASP 13. The complex contains four separate subunits that were modeled individually. ​/Science Sign up for our daily newsletter Get more great content like this delivered right to you! Country Data: abcdefg hijkl mnop qrstu vwxyz 1234 56789 Turns out mastering chess and Go was just for starters. On 2 December, the Google-owned artificial intelligence firm DeepMind took top honors in the 13th Critical Assessment of Structure Prediction (CASP), a biannual competition aimed at predicting the 3D structure of proteins.The contest worked like this: Competing teams were given the linear sequence of amino acids for 90 proteins for which the 3D shape is known but not yet published. Teams then computed how those sequences would fold. Though London-based DeepMind had not previously joined this competition, the predictions of its AlphaFold software were, on average, more accurate than those of its 97 competitors.How close was the race? By one metric, not very. For protein sequences for which no other information was known—43 of the 90—AlphaFold made the most accurate prediction 25 times. That far outpaced the second place finisher, which won three of the 43 tests. Andriy Kryshtafovych/University of California, Davis 50 25 Click to view the privacy policy. Required fields are indicated by an asterisk (*) So AlphaFold lapped the competition? Well, not exactly. When you track how much AlphaFold won or lost by in each case, the results look much closer. That’s shown in the graph below. It shows AlphaFold’s performance on the vertical axis and that from the best other group on the horizontal axis. Points above the red line show predictions where AlphaFold won. Points below, it lost. And those on the red line were essentially a tie. The upshot? AlphaFold won a lot of rounds, with an average margin of 15% accuracy improvement over other groups on the toughest 43 tests, says John Moult, CASP’s lead organizer and a computational biologist at the University of Maryland in Rockville. Email Protein Data Bank So, what was going on? David Baker, a CASP organizer, participant, and computational modeling expert at the University of Washington in Seattle, notes that DeepMind’s scientists built on two algorithm strategies pioneered by others. First, by comparing vast troves of genomic data on other proteins, AlphaFold was able to better decipher which pairs of amino acids were most likely to wind up close to one another in folded proteins. Second, related comparisons also helped them gauge the most probable distance between neighboring pairs of amino acids and the angles at which they bound to their neighbors. Both approaches do better with the more data they evaluate, which makes them more apt to benefit from machine learning computer algorithms, such as AlphaFold, that solve problems by crunching large data sets. DeepMind scientists “are extremely good at machine learning and have a superb team” with deeper pockets than most academic groups, Baker says.Still, not bad for a newbie. “Give them credit,” adds John Moult, another CASP organizer and a computational biologist at the University of Maryland in Rockville. “They came from nowhere.” 50 100 25 25 0 Google’s DeepMind aces protein folding 100 DeepMind’s AlphaFold 75 Ready, set, fold! Points above the red line show protein-folding predictions where AlphaFold won. It lost those below the line. Those on the line were essentially a tie. Data: abcdefg hijkl mnop qrstu vwxyz 1234 56789 75 0 0 75 Other top competitors ​Data: Andriy Kryshtafovych, U.C. Davis Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe 50 By Robert F. ServiceDec. 6, 2018 , 12:05 PMlast_img read more

Trump White House tried to bury US climate report That has only

first_imgPresident Donald Trump By Scott Waldman, E&E NewsNov. 29, 2018 , 9:07 AM Trump White House tried to bury U.S. climate report. That has only generated more attention Read more… Originally published by E&E NewsU.S. President Donald Trump administration’s rebuke of a 1700-page climate report produced by 13 federal agencies has fueled a week of media coverage that shows little sign of dying down.The National Climate Assessment was dropped on Black Friday, an obscure time that was widely perceived as an attempt to bury the report. Instead, it’s been given extra life. Gage Skidmore/Flickr (CC BY-SA 2.0) Sign up for our daily newsletter Get more great content like this delivered right to you! Country Click to view the privacy policy. Required fields are indicated by an asterisk (*) Email Climate scientists have appeared on national and international television shows for days, newspapers continue to pump out headlines, and the president himself is being questioned about it. Administration officials have said the report is fraudulent or exaggerated, which produces another wave of fact-checking.Some Republicans have reacted by showing support for the report, including Senator Thom Tillis (R–NC). That shows some members of the party are embarrassed by the week of denials, said Bob Inglis, a former Republican congressman who is now executive director of republicEn, which works to get conservatives to act on climate policy.”Trump is clearly becoming the climate disputer in chief and looking like a pretty silly caricature, where he is standing on his superstition about climate when the scientists are telling us about the data,” Inglis said. “I think the adults in the room, like Sen. Tillis, are doing what you would expect a responsible lawmaker to do, which is pay attention to the scientists who are presenting data and to turn away from some sort of superstitious disbelief of climate science.”Before the report was released, some critics of the administration were concerned that the White House would try to alter its findings. Instead, the administration allowed the report to be released and then questioned its credibility.On Tuesday, White House press secretary Sarah Huckabee Sanders said the report was “not based on facts.” Trump has said he did not believe the scientific assessment. Then he elaborated on his views.”One of the problems that a lot of people like myself — we have very high levels of intelligence, but we’re not necessarily such believers,” he told The Washington Post in an Oval Office interview. “You look at our air and our water, and it’s right now at a record clean.”Trump then repeated a claim that is popular among those who deny climate science: that scientists used to warn about global cooling in the 1970s. Early in his presidency, Trump was shown a fake Time magazine cover that features a supposed article about global cooling. In reality, scientists have known since the 19th century that adding carbon dioxide into the atmosphere will raise the Earth’s temperatures.”If you go back and if you look at articles, they talked about global freezing, they talked about at some point the planets could have freeze to death, then it’s going to die of heat exhaustion,” Trump said.Administration officials have said that the report is based on “extreme scenarios” and faulty assumptions and that it was not transparent. Trump’s allies have said that climate scientists are getting rich off the report. Both of those points have been refuted.The report includes lower- and higher-emissions scenarios, not just extreme projections, scientists have pointed out. Researchers did not receive compensation for writing the report.Yesterday, Andrew Wheeler, the acting administrator of the Environmental Protection Agency (EPA), said the report was “interesting.” He then questioned the climate models that led to its assumptions.”We need to take a look at the modeling that is used for the next assessment,” he said at an event hosted by The Washington Post.The administration’s response has kept climate scientists busy. Katharine Hayhoe, an atmospheric scientist at Texas Tech University in Lubbock, and one of the report’s leading authors, said she has spent every day since its release fielding media questions. She attributes the attention to the White House’s response as well as to the specificity of the latest volume, which shows regional effects of climate change, she said.The more the administration talks about the report, or tries to downplay it, the more news it gets, she said. That, in turn, has more people paying attention to its findings.”For the majority of people who are listening, this coverage is positive, because it reinforces the messages again and again that yes, the science is certain,” Hayhoe said. “It reinforces the message that scientists agree, and also it directly attacks what I see as the most dangerous message, which is that it doesn’t matter to me.”The idea that the administration tried to hide the report appears to be fueling coverage, said Robert Kopp, a lead author on the first volume of the assessment and director of the Rutgers University Institute of Earth, Ocean and Atmospheric Sciences in New Jersey. The assessment, he said, is inherently difficult to report on because it’s so detailed and the overarching messages are all things that have received coverage in the past.”Probably ‘The Trump administration tried to bury the report’ is a more attractive headline for journalists than ‘Trump administration releases report confirming the same thing reports have been confirming for decades,'” said Kopp.One reason the administration is struggling with its response to the report is because it lacks climate science experts, said Marlo Lewis, a senior fellow at the conservative Competitive Enterprise Institute, which has attacked established climate science. He said any response to the report will bring a new wave of critical coverage. Instead, he said, the White House should promote energy generation.”What would help in the long run is an in-house capability to make the moral, economic, and scientific case for free-market energy,” Lewis wrote in an email. “That could help Trump immensely with his base, party, and the general public, especially if the economy remains strong over the next two years.”The administration didn’t have an adequate response to the report because “they were surprised by it,” said Steve Koonin, a physicist at New York University in New York City who worked with former EPA Administrator Scott Pruitt to formulate a climate science debate. Koonin criticized some of the report’s economic conclusions in a Wall Street Journal opinion piece this week, saying that they were overblown. Yesterday, he said one reason the administration was caught off guard is because it hasn’t adequately staffed the Office of Science and Technology Policy.”They just have to pay much more attention to what these reports say and ask the hard questions of people writing the reports,” said Koonin, “the kind of questions that any serious executive would ask of people who are doing analysis for them. We know how to do this in the national security space; why don’t we do it here?”Reporter Hannah Northey contributed.Reprinted from Climatewire with permission from E&E News. Copyright 2018. E&E provides essential news for energy and environment professionals at www.eenews.net. Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwelast_img read more

Humpback whale songs undergo a cultural revolution every few years

first_img Humpback whale songs undergo a ‘cultural revolution’ every few years imageBROKER/Alamy Stock Photo The revolutionary songs may be less complex than the old ones because the whales can only learn a certain amount of new material at a time, the scientists conclude. That could mean that although humpback whales are still the crooners of the sea, their learning skills are a bit limited. By Virginia MorellNov. 20, 2018 , 7:01 PM Like any fad, the songs of humpback whales don’t stick around for long. Every few years, males swap their chorus of squeaks and groans for a brand new one. Now, scientists have figured out how these “cultural revolutions” take place.All male humpbacks in a population sing the same song, and they appear to learn new ones somewhat like people do. Males in the eastern Australian population of humpbacks, for example, pick up a new song every few years from the western Australian population at shared feeding grounds or while migrating. Over the next few years, the songs spread to all South Pacific populations.To understand how the whales learn the novel ballads, scientists analyzed eastern Australian whale songs over 13 consecutive years. Using spectrograms of 412 song cycles from 95 singers, the scientists scored each tune’s complexity for the number of sounds and themes, and studied the subtle variations individual males can add to stand out. Complexity increased as the songs evolved (as heard in the video below), the team reports today in the Proceedings of the Royal Society B. But after a song revolution, the ballads became shorter with fewer sounds and themes.last_img read more

Food prepared by inmates of Keralas Viyyur Jail to now go online

first_imgBy Express Web Desk |Kochi | Updated: July 11, 2019 11:18:59 pm Post Comment(s) Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield After Masood Azhar blacklisting, more isolation for Pakistan Advertising Nirmalanandan Nair, the superintendent of the Viyyur central jail, told indianexpress.com that the idea germinated from Rishiraj Singh, the popular IPS officer currently serving as DGP in charge of jails and correctional services in the state. Nair said Singh was of the opinion that since the food prepared by jail inmates was popular among the public for its taste and value for money, it must be taken further to those sitting at home through the online delivery system.While the over-the-counter system will continue in front of the Viyyur jail, officials have devised a special menu for online delivery. Titled the ‘Freedom Combo Lunch’, it includes 300 grams of biryani rice, a roasted chicken leg piece, 3 rotis, 1 chicken curry, pickle, salad, a bottle of mineral water and a cup cake for dessert. The combo, priced at an attractive Rs 127, comes packed with a plantain leaf as well.“We will start the online delivery system on July 11 and will see how it goes. Our initial plan is to sell about 100 combos a day. If there’s more demand, we will increase supply. Swiggy said their men can deliver the food in a six-kilometre radius of the prison,” said Nair, over phone. Virat Kohli won’t have a say in choosing new coach At present, the jail sells around 25000-30000 rotis, 500-600 chicken biryanis and 300 vegetable and chicken curries a day through its counter. The food is prepared solely by around 100 male inmates who are classified into different teams cooking different items. They are supervised by prison officials for round-the-clock quality control. Recently, a spanking new kitchen, built at a cost of Rs 50 lakh with state-of-the-art appliances, was inaugurated at the Viyyur jail.Contact numbers are provided on food packets to get feedback from the public. The inmates are paid wages to the tune of Rs 150 per day for their work and revenue from the food business goes into refurbishing and maintenance of the jails. Top News kerala jail food, kerala jail inmates food, kerala Viyyur Jail, Viyyur Jail inmates food, prison food kerala, swiggy, swiggy kerala jail collaborate The initiative will be initially rolled out of the Viyyur Central Jail in ThrissurSensing huge potential in the online food delivery space, the Freedom Food Factory – the enterprise selling food prepared by inmates at Kerala’s prisons – has decided to tie-up with Swiggy, an industry giant, to break new ground. The initiative will be initially rolled out of the Viyyur Central Jail in Thrissur. At present, food such as the likes of biryani, roti and curries are sold only from the counter in front of the prison. Advertisinglast_img read more

Official Lightning caused Jim Beam bourbon warehouse fire

first_img After Masood Azhar blacklisting, more isolation for Pakistan News outlets report cabinet spokesman John Mura confirmed the cause Wednesday. The fire started July 2, destroying the Woodford County warehouse and about 45,000 barrels of bourbon.Some alcohol flowed from Glenns Creek to the Kentucky River, and then to the Ohio River where fish died. Jim Beam and environmental officials used equipment to restore oxygen to the water in an attempt to minimize the number of fish killed.The cabinet said on Facebook that the alcohol plume is dissipating as it moves along the Ohio River.Mura says the cabinet plans to issue Jim Beam a notice of violation that could lead to a fine. Advertising Post Comment(s) Top News Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Cabinet asks finance panel to consider securing funds for defence jim beam warehouse fire, fire at jim beam warefouse, warehouse fire at jim beam, jim beam fire, jim beam warehouse, world news, Indian Express The fire started July 2, destroying the Woodford County warehouse and about 45,000 barrels of bourbon. (AP)The Kentucky Energy and Environment Cabinet said lightning sparked the fire at a Jim Beam warehouse that caused bourbon to leak into creeks and rivers. By AP |Versailles (france) | Published: July 11, 2019 8:45:45 amlast_img read more

Heavy rains cause flash floods in Washington DC vehicles stranded in high

first_imgThe news broadcaster reported that in the last one hour, areas around the Potomac river have witnessed heavy flooding. Authorities have begun operations to rescue people who are stranded in their vehicles in the affected area.SEE PHOTOS | Heavy rains strand Washington drivers, flood White House basementAreas of concern reportedly include the Great Falls, Virginia, area and southeastern Montgomery County, Maryland as heavy rains continue to batter much of the area, including the District of Columbia.Flash Flood Warning continues for Washington DC, Alexandria VA, Bowie MD until 1:45 PM EDT pic.twitter.com/F17edS866Z— @NWSFlashFlood (@NWSFlashFlood) July 8, 2019Stormy conditions have affected the air traffic as well as aircraft heading towards Reagan National have been grounded along with reports of departure delays by at least one hour. Water entered into the press workspace in the basement near the White House’s West Wing as government employees worked to drain puddles of standing water with wet vacs.Lord behold, the Washington swamp in all of it’s glory on a #MondayMorning. #WashingtonDC #WashingtonFloods. pic.twitter.com/fGADHcnv7h— 🐧Marcus Foo🇦🇺 (@AStrongerOZ) July 8, 2019“Excessive runoff from heavy rainfall will cause flooding of small creeks and streams, urban areas, highways, streets and underpasses as well as other drainage areas and low lying spots,” the weather service was quoted as saying by CNN.Got to see a waterfall today during my morning commute #VSquare pic.twitter.com/e3i0sCmxGo— Hugo Dante (@HugoDanteJr) July 8, 2019“Most flood deaths occur in vehicles,” according to the National Weather Service, which advised against driving into “any area where water covers the road.”A spokesman for the Montgomery County Fire Department was quoted as saying by the Associated Press that emergency workers in the Maryland county used boats for dozens of rescues, rescuing people from flooded cars. Pete Piringer stated that he didn’t immediately receive any reports of storm-related injuries.(With inputs from CNN) Donald Trump loses badly in Wyoming, Washington DC US police announces reward for leads in murder of Indian mother, son Heavy rains cause flash floods in Washington DC, multiple vehicle stranded in high water CNN reported that stormy conditions have affected the air traffic as well as aircraft heading towards Reagan National have been grounded along with reports of departure delays by at least one hour. (Photo courtesy: Twitter)Heavy rains have caused flash floods in areas of Washington DC in the United States, CNN reported. The flooding prompted the National Weather Service to issue a flash flood emergency until 1:45 pm (local time). 2 Comment(s) By Express Web Desk |New Delhi | Updated: July 9, 2019 9:58:45 am Panic at Washington DC’s Pride Parade sends people running Advertising Related News last_img read more

Sri Lanka PM to appear before Parliamentary Committee probing Easter attacks

first_img Related News The prime minister made the remarks after his government on Thursday defeated the no-confidence motion that accused it of failing to prevent the Easter Sunday bombings despite receiving intelligence inputs from India.The motion, moved by the Marxist Janatha Vimukthi Peramuna, was defeated by a vote of 119-92 after two days of debate.Emphasising that his government will uncover the truth behind the attacks, Wickremesinghe, in a statement, said the committee has been set-up to probe the lapses in communicating intelligence warnings which were received prior to the tragedy, the Times Online reported. He said that the government hopes to adopt new laws to curb global terrorism while looking forward to working with international intelligence agencies as well.Rejecting claims that the country’s activities had been stalled since the terror attacks, he said that several projects concerning housing, economy and employment are going on, the report said.Wickremesinghe said that steps have been taken to revive the tourist industry which had faced adverse impacts owing to the bombings.Nine suicide bombers carried out a series of devastating blasts on April 21 that tore through three churches and three high-end hotels frequented by tourists in Sri Lanka’s deadliest terror attack since the devastating civil war with the Liberation Tigers of Tamil Eelam (LTTE) ended in 2009.The Islamic State claimed the attacks, but the government blamed local Islamist extremist group National Thawheed Jamaath (NTJ) for the bombings which killed 258 people, including 11 Indians, and injured hundreds. Sri Lanka still faces threat of ISIS terror attacks: PM Wickremesinghe Advertising By PTI |Colombo | Published: July 13, 2019 3:46:37 pm sri lanka, sri lanka economy, sri lanka loan, sri lanka bank loans, sri lanka asian infrastructure investment bank, asian infrastructure investment bank, sri lanka terrorist attack, sri lanka political turmoil, sri lanka 1 billion dollars loan, world news, indian express Sri Lanka PM Ranil Wickremesinghe said that the government hopes to adopt new laws to curb global terrorism (AP)Sri Lankan Prime Minister Ranil Wickremesinghe said that he would appear before the Parliamentary Select Committee probing the Easter Sunday attacks that claimed 258 lives and would provide all available information, according to a media report. Advertising Sri Lankan PM Wickremesinghe says he is opposed to capital punishment Sri Lanka’s PM says potential bombers at large, suspects ‘may go for suicide attack’ Post Comment(s)last_img read more

Serious Efforts to Use Tech for Good Shine Through

first_imgThe HP Sprocket 2nd Edition, launched last week, is another huge indicator that printers are coming back. HP’s Efforts It’s a recurring theme that we — and by “we” I mean technology analysts and journalists — should give more focus to the activities of firms that are behaving well over the misbehavior of those that are not.People learn by example, and if the only examples all of us — including myself — repeatedly are pounding is that big companies are unethical, do bad things to their customers and environment, and largely are run by *ssh*les, then we’ll promote that bad behavior. Folks will think that everyone else does it, so why shouldn’t they?I think it far better that we focus more on firms that are trying to make the world a better place in order to promote that behavior and actually help make the world a better place. A number of global companies have been busting their humps to do exactly that. HP is one of the firms aggressively going down this path, promising to improve educational opportunities for 100 million students by 2025. This isn’t a trivial number, and education is believed to be one of the core elements holding emerging economies and economically troubled countries back.Lack of education has had an adverse impact on many countries’ gross domestic products, the competence of their governments, and their ability to take care of and protect their populations. Educated people have choices. Education is a force multiplier, making citizens more productive. Learning engages people and keeps them from becoming social problems — or worse, enemy combatants and terrorists.Technology offerings for students affected by the war in Syria allow them to learn how to use the Web more effectively, to help dig out of the mess their country is in so it can return to being viable. This video, narrated by George Clooney, showcases both the scale of the commitment and some of the progress to date. For much of this year, technology companies have been showcased in a very poor light.There was the coverage of Facebook’s adverse impact on the 2016 U.S. elections (and other elections worldwide); there was Intel’s security scandal and the firing of its CEO following reports suggestive of insider trading; there was the Google+ breach and coverup; and there have been incidents of nastiness and bullying across all the social networks.As a result, many folks, particularly governments, have been looking at tech firms very unfavorably.Several firms have been moving aggressively to buck this trend, however.Dell has provided substantial funding for pro-women programs led by Karen Quintos.Cisco has made meaningful contributions in cities where it operates, both in responding to disasters and funding programs to uplift the poor.Microsoft has flipped to taking the lead in providing transparency and improving working conditions.HP has undertaken major efforts to address different types of social injustice.HP’s latest effort, in conjunction with the Clooney Foundation for Justice, is a case in point: an impressive initiative to supply and fund schools in places like war-torn Syria.I’ll share my observations on the importance of efforts like these and then close with my product of the week: the Sprocket 2nd Edition, an update to one of my favorite little HP products. Girl Rising HP Sprocket 2nd Edition Photo Printer We’ve been complaining about inequality for decades, but it is only when people roll up their sleeves and drive change that change happens. These women, heroes all, have done exactly that. Some steps may be larger than others, but every step gradually makes the world a better place for our mothers, daughters, wives and female friends to live. center_img HP is doing very well this year. Out from under the cloud that smothered it for much of the last decade, with powerful focused leadership and a CEO who has forged an impressive team, the firm arguably is stronger than it has been in decades. Rather than using that strength inappropriately or only to increase revenue, HP has been using part of its strength to make the world a better place, particularly for women.I think that the more we promote and encourage this behavior, the more firms will emulate it, and if this increases in scale, our efforts will improve the world for everyone. Rob Enderle has been an ECT News Network columnist since 2003. His areas of interest include AI, autonomous driving, drones, personal technology, emerging technology, regulation, litigation, M&E, and technology in politics. He has an MBA in human resources, marketing and computer science. He is also a certified management accountant. Enderle currently is president and principal analyst of the Enderle Group, a consultancy that serves the technology industry. He formerly served as a senior research fellow at Giga Information Group and Forrester. Email Rob. Yep, I didn’t really believe this either, but HP, which dominates this industry, has been showing impressive growth in both printers and supplies. This is largely because it rethought them and aggressively moved on opportunities like 3D printing — and this smartphone printer.One of the big surprises was how popular their first Sprocket Printer became. It was primarily a printer for smartphones, which you could carry in your pocket to share pictures you took with your phone immediately.In use, it reminds me a lot of the old Polaroid experience, but without the nasty waiting period or the need to deal with the waste parts of that process. You just send the picture to the printer and in a few seconds, you get a full color picture you can give to your relative or friend as a keepsake, while you keep the digital copy on your phone. The product defines easy set up and use and it is surprisingly popular with millennials, who likely never saw a Polaroid and were expected to go fully digital.There is something about having a picture you can hold in your hands that has transcended generations, however, and created a new category of products. In a way, the Sprocket is HP’s iPod. What I think is particularly interesting is that it largely targets a female audience. In fact, the target demographic is women between the ages of 16 and 24.For instance, rather than the typical male-oriented colors of black, white, gold and silver, the Sprocket 2nd Edition comes in Luna Pearl, Noir, Blush and Lilac.Improvements to this product — which, as you would expect from HP, leads its segment — are sharper colors and higher speed. Some new features, like multi-user functionality and an augmented reality function I haven’t used yet, have received mixed reviews. One cool improvement is that this printer is always on. Earlier versions required you to power up and connect the printer each time you used it.The included app allows you to make basic image fixes like crops, contrast, brightness and color levels. You can add borders and text (make a custom-printed business card, for example). Print price also has dropped from around US$.65 per print to $.45 per print, which is a nice improvement all by itself. The printer itself costs $129.99.What I like the most is that this is one of the few products designed specifically for women that women actually like — it has been surprisingly successful in its earlier iterations. As a result, the new HP Sprocket 2nd Edition is my product of the week. The opinions expressed in this article are those of the author and do not necessarily reflect the views of ECT News Network. Wrapping Up: Doing Well By Doing Good HP also has provided substantial support to the Girl Rising movement. One of its focuses is to share stories about people who use technology to make the world a better place for girls and women. The idea is that when people learn of the successful programs undertaken by others, they are encouraged that these programs can and do work, and they are motivated to emulate them.This in turn should have a cumulative impact on how people perceive women and open more opportunities to women, and build on the increasing sense that women aren’t standing alone or just being given lip service.HP is standing up and being counted in an effort to do more than complain about the unfairness of it all, and instead to address the unfairness and bring real and measurable change to a world in which female inequality is still very pronounced.Last week, the winners of the Girl Rising Creative Challenge were announced. All are young women working aggressively to change gender inequality in the world. The people are real, the stories are compelling. I was particularly taken by the fact that none of these women are complaining — they are working impressively to drive real change. Doing Well by Doing Goodlast_img read more

Loyola launches research program to study new treatment for stroke spinal cord

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Oct 6 2018Loyola Medicine has launched a research program to study a new treatment approach for stroke and spinal cord injury patients that involves electrically stimulating nerves.The Kalmanovitz Central Nervous System Repair Research Program is funded by a $500,000 gift from the Kalmanovitz Charitable Foundation. The program is directed by Loyola neurosurgeon Russ Nockels, MD, who has been treating and studying spinal cord injuries for 30 years.The goal of the research is to improve a patient’s ability to function and to develop a relatively inexpensive treatment that could be adapted worldwide. While such treatment isn’t expected to completely reverse the effects of a severe stroke or paralysis from spinal cord injury, it could improve the patient’s quality of life.”We’re trying to move the needle,” said Dr. Nockels, a professor in Loyola Medicine’s department of neurological surgery. “The generous donation from the Kalmanovitz Charitable Foundation will enable us to accelerate our research, which ultimately could significantly improve the lives of stroke and spinal cord injury patients.”Related StoriesMeasuring blood protein levels in diabetic patients to predict risk of strokeInvestment in stroke prevention interventions is good for the futurePeople who worked long hours have higher risk of stroke, shows studyThe theory behind electrical stimulation treatment is based on the central nervous system’s ability to adapt to a stroke or spinal cord injury by changing its wiring and circuitry. (This ability is called “activity-dependent plasticity.”) A simple activity such as moving an arm or a leg can enhance plasticity and thus improve recovery from a spinal cord injury or stroke. Previously it was believed that function could not be restored following brain and spinal cord injuries. Damage to the central nervous system has been resistant to treatment efforts. However, with more research, such injuries eventually may be repairable.A preliminary Loyola study found that electrical stimulation appeared to enhance activity-dependent plasticity. Researchers confirmed that stimulation resulted in significantly greater functional recovery regarding spinal cord healing compared to when stimulation was not used.Following up on these promising results, Loyola researchers are developing a system that could be applied directly to patients. Such treatments would be offered during the critical first two weeks or so following the spinal cord injury. Once the electrical stimulation system is perfected, the Kalmanovitz Central Nervous System Repair Research Program would organize a multicenter trial to test it on newly injured spinal cord patients.Source: http://www.luhs.org/last_img read more

Study Affordable housing with supportive social services for senior citizens can reduce

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 12 2018Investing in affordable housing that offers supportive social services to senior citizens on Medicare has the potential to reduce hospital admissions and the amount of time needing inpatient hospital care by better managing chronic health conditions, according to a Rutgers study.The study was recently published in the journal Health Affairs.While prior research has shown that housing conditions affect health outcomes of the elderly, there is limited information about the effect support services – including physical and psychological assessments; counseling and advocacy; health education; wellness and physical activity and socialization programs; — have on the well-being of seniors and the costly hospital services for Medicare beneficiaries.Related StoriesDanbury Hospital launches ‘Healing Hugs’ for its most vulnerable patientsHave cancer, must travel: Patients left in lurch after hospital closesFeeling safe and good sleep at night matter most to sick kids in hospitalThe research was led by Michael Gusmano, an associate professor of health policy at Rutgers School of Public Health and member of the Rutgers Institute for Health, Health Care Policy and Aging Research. The study examined whether a program provided to elderly Medicare beneficiaries through a nonprofit, community-based group in Queens, New York, would reduce hospital use, including hospital discharges for ambulatory care-sensitive conditions that, if managed well, should not require admission to a hospital.According to Gusmano, research showed that discharge rates and length of hospital stays were lower in Medicare beneficiaries who lived in the housing environment that offered supportive social services, as compared to seniors in the same neighborhood living without these amenities. This suggests that continued investment into housing with supportive social services can reduce costly hospital stays and decrease spending for vulnerable older adults, he said.”These findings are consistent with the claim that housing programs of this sort help people stay healthy and, perhaps more importantly, help them receive health and social services that allow them to manage their chronic conditions,” said Gusmano. “By receiving timely and appropriate support in the community this vulnerable population may be able to avoid hospitalization or at least use it less often.”Source: https://news.rutgers.edu/elderly-housing-supportive-social-services-can-reduce-costly-hospital-use-rutgers-study-finds/20181010#.W7979ZNKg8Ylast_img read more

Multigene test is a helpful decision making tool in breast cancer treatment

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Dec 7 2018Multigene tests have been used in breast cancer treatment to assess the risk of metastasis for several years. A team at the Breast Cancer Center at the Technical University of Munich’s (TUM) Klinikum rechts der Isar has now presented results based on data collected in its routine clinical work. These results show that the multigene test used at the university hospital is indeed helpful in making more targeted use of chemotherapy treatments and thus improves prognosis of breast cancer patients.Since November 2011, the Gynecological Clinic at Klinikum rechts der Isar has used a multigene test for patients with early hormone receptor-positive, HER2-negative breast cancer. Using tissue samples and other clinical indicators, the test helps to determine a patient’s risk of metastasis. “Based on the test results, which combine molecularbiological properties of the tumor along with the individual factors of tumor size and the presence of cancer in lymph nodes, doctors decide whether chemotherapy is recommended in addition to the surgical removal of the tumor followed by anti-hormone treatment,” explains Prof. Marion Kiechle, the Director of the Gynecological Clinic. “In case of a low metastasis risk, chemotherapy may place an unnecessary burden on the patient. But in case of a high risk, it may prevent tumors from relapsing later.”Related StoriesNew study to ease plight of patients with advanced cancerUsing machine learning algorithm to accurately diagnose breast cancerHow cell-free DNA can be targeted to prevent spread of tumorsAt the San Antonio Breast Cancer Symposium in the USA, one of the world’s most important congresses in that field, Dr. Johannes Ettl, Head Physician of the Gyneco-Oncological Outpatient Clinic, Technical University of Munich, Germany has now presented the results of an independent study not commissioned by a test manufacturer of the test used at the Breast Center.373 patients testedFor the study, Dr. Ettl and his team tracked 373 breast cancer patients from the start of initial treatment and the related multigene test. The test indicated a low risk for 238 patients (63.8%) and a high risk for 135 (36.2%). After a median follow up of 3.5 years, the risk for disease recurrence was twice as high in the high-risk group as in the low-risk group. Similarly, high risk patients were at five-fold increased risk of developing metastases in other organs. The low-risk and high-risk patients who received chemotherapy in addition to anti-hormone tablets had three-year disease free survival rates of 96.6% and 96.3%, respectively. By contrast, for high-risk patients who did not receive chemotherapy despite the doctors’ recommendation based on the test results, the rate was only 91.5%.”Our health care study has delivered the first data from routine clinical practice indicating that the test does, in fact, provide useful input when deciding on chemotherapy,” says Prof. Kiechle. “Gene signature tests are important tools that help us to make more targeted use of chemotherapy treatments, both by limiting unnecessarily stressful treatments and avoiding the potentially serious consequences of rejecting chemotherapy in case of high metastasis risks.” Source:https://www.tum.de/en/about-tum/news/press-releases/detail/article/35125/last_img read more

Therapy derived from parasitic worms helps protect against one of chemotherapys side

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 8 2019A therapy derived from the eggs of parasitic worms helps to protect against one of chemotherapy’s debilitating side effects by significantly downregulating major proinflammatory pathways and reducing inflammation, indicates the first transcriptome-wide profiling of the bladder during ifosfamide-induced hemorrhagic cystitis.The experimental model study findings were published online Feb. 7, 2019, in Scientific Reports.With hemorrhagic cystitis, a condition that can be triggered by anti-cancer therapies like the chemotherapy drug ifosfamide and other oxazaphosphorines, the lining of the bladder becomes inflamed and begins to bleed. Existing treatments on the market carry their own side effects, and the leading therapy does not treat established hemorrhagic cystitis.Around the world, people can become exposed to parasitic Schistosoma eggs through contaminated freshwater. Once inside the body, the parasitic worms mate and produce eggs; these eggs are the trigger for symptoms like inflammation. To keep their human hosts alive, the parasitic worms tamp down excess inflammation by secreting a binding protein with anti-inflammatory properties.With that biological knowledge in mind, a research team led by Michael H. Hsieh, M.D., Ph.D., tested a single dose of IPSE, an Interleukin-4 inducing, Schistosoma parasite-derived anti-inflammatory molecule and found that it reduced inflammation, bleeding and urothelial sloughing that occurs with ifosfamide-related hemorrhagic cystitis.In this follow-up project, experimental models were treated with ifosfamide to learn more about IPSE’s protective powers.The preclinical models were given either saline or IPSE before the ifosfamide challenge. The bladders of the experimental models treated with ifosfamide had classic symptoms, including marked swelling (edema), dysregulated contraction, bleeding and urothelial sloughing. In contrast, experimental models “pre-treated” with IPSE were shielded from urothelial sloughing and inflammation, the study team found.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerResearchers identify gene mutations linked to leukemia in children with Down’s syndromeStudy reveals link between inflammatory diet and colorectal cancer riskTranscriptional profiling of the experimental models’ bladders found the IL-1-B TNFa-IL-6 proinflammatory cascade via NFkB and STAT3 pathways serving as the key driver of inflammation. Pretreatment with IPSE slashed the overexpression of Il-1b, Tnfa and Il6 by 50 percent. IPSE drove significant downregulation of major proinflammatory pathways, including the IL-1-B TNFa-IL-6 pathways, interferon signaling and reduced (but did not eliminate) oxidative stress.”Taken together, we have identified signatures of acute-phase inflammation and oxidative stress in ifosfamide-injured bladder, which are reversed by pretreatment with IPSE,” says Dr. Hsieh, a urologist at Children’s National Health System and the study’s senior author. “These preliminary findings reveal several pathways that could be therapeutically targeted to prevent ifosfamide-induced hemorrhagic cystitis in humans.”When certain chemotherapy drugs are metabolized by the body, the toxin acrolein is produced and builds up in urine. 2-mercaptoethane sulfonate Na (MESNA) binds to acrolein to prevent urotoxicity. By contrast, IPSE targets inflammation at the source, reversing inflammatory changes that damage the bladder.”Our work demonstrates that there may be therapeutic potential for naturally occurring anti-inflammatory molecules, including pathogen-derived factors, as alternative or complementary therapies for ifosfamide-induced hemorrhagic cystitis,” Dr. Hsieh adds. Source:https://childrensnational.org/last_img read more

Scientists target metastasis in the battle against cancer

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 29 2019An experimental combination drug therapy attacking the DNA integrity of cancer cells is showing promise for a possible new cancer therapy in the future.Scientists at the University of Alberta used two drugs together to enhance DNA damage to human breast cancer cells in mice and reduce their capacity to repair themselves. By doing so, the researchers were able to dramatically shrink tumors and prevent metastasis in the mice.”Most cancers don’t kill patients because of the primary tumor. It’s nearly always the metastasis that kills,” said Armin Gamper, an assistant professor of oncology at the U of A.”Traditionally we find that the subset of cancer cells responsible for metastasis is especially resistant to treatment. But when we combined the two drugs, it made these cells as sensitive as the other cancer cells. This is something really new that has never been observed before.”Compared with normal cells, cancer cells have higher levels of DNA damage. The experimental treatment was designed to selectively kill cancer cells by targeting their DNA repair capability. With the treatment, the researchers found that cancer cells attempting to multiply with unrepaired DNA failed and died in the process. The team also found the treatment had few side-effects compared with cancer treatments such as traditional chemotherapy.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerUsing machine learning algorithm to accurately diagnose breast cancerCancer killing capability of lesser-known immune cells identified”The combination was very well tolerated,” said Gamper, also a member of the Cancer Research Institute of Northern Alberta. “If we see that this works as well in patients as it does in mice, at one point it might, at least in some cases, replace the traditional chemotherapy because it seems to have far fewer side-effects.”The drugs used are already being tested in clinical trials, on their own or in combination with other treatments–but not together. According to the team, that will greatly speed the process of starting a new clinical trial combining the two.Gamper and his research team are partnering with Alberta Health Services clinicians at the Cross Cancer Institute in hopes of starting a phase one clinical trial to test how people tolerate the drug combination.In the meantime, the researchers are expanding their work to other types of cancer and also aim to identify biomarkers–biological indicators of which patients would most benefit from the new treatment. Doing so would allow them to tailor a precise cancer therapy to the individual patient.”The idea behind this combination was that it would target many different cancers, not just breast cancer,” explained Gamper. “So we would like to test it in others that we know have a high level of DNA damage to start with, like ovarian cancers, colon cancers and some other types of breast cancer. We’ll start with those first and then see later how it affects other cancers that don’t have such high DNA damage levels to start with.”Source: https://www.folio.ca/researchers-target-metastasis-in-fight-against-cancer/last_img read more

Researchers develop simple quick technique for gene editing in rice blast fungus

first_imgSource:Tokyo University of ScienceJournal reference:Yamato, T. et al. (2019) Single crossover-mediated targeted nucleotide substitution and knock-in strategies with CRISPR/Cas9 system in the rice blast fungus. Scientific Reports. doi.org/10.1038/s41598-019-43913-0. Reviewed by James Ives, M.Psych. (Editor)May 24 2019CRISPR/Cas9 is now a household name associated with genetic engineering studies. Through cutting-edge research described in their paper published in Scientific Reports, a team of researchers from Tokyo University of Science, Meiji University, and Tokyo University of Agriculture and Technology, led by Dr Takayuki Arazoe and Prof Shigeru Kuwata, has recently established a series of novel strategies to increase the efficiency of targeted gene disruption and new gene “introduction” using the CRISPR/Cas9 system in the rice blast fungus Pyricularia (Magnaporthe) oryzae. These strategies include quicker (single-step) gene introduction, use of small homologous sequences, and bypassing of certain prerequisite host DNA “patterns” and host component modification.The team led by Dr Arazoe and Prof Kuwata has devised simple and quick techniques for gene editing (target gene disruption, sequence substitution, and re-introduction of desired genes) using CRISPR/Cas9 in the rice blast fungus Pyricularia (Magnaporthe) oryzae, a type of filamentous fungus. Spurred on by encouraging results, the researchers surmise, “Plants and their pathogens are still coevolving in nature. Exploiting the mutation mechanisms of model pathogenic fungi as a genome editing technique might lead to the development of further novel techniques in genetic engineering.”The working component of the CRISPR/Cas9 system binds to the target gene region (DNA) and causes a site-specific double-stranded break (DSB) in the DNA. Effective binding of this component requires a certain “motif” or “pattern” called the protospacer-adjacent motif (PAM), which follows downstream of the target gene region.Most genome editing techniques require DSBs induced at the target site, which trigger DNA “repair” pathways in the host. Homologous recombination (HR) is a mechanism for repair of DSBs, and it is useful because it adds complementary sequences. However, the underlying methodology is laborious, and its efficiency conventionally depends on external factors such as the host properties as well as PAMs. HR can be divided into two pathways: “noncrossover” (gene conversion) and “crossover” type. Crossover-type repairs are known to occur in cells that undergo meiosis. However, the understanding of their role in cells that undergo mitosis is limited, and such information on filamentous fungi is virtually unavailable. It is this gap in knowledge that the researchers were looking to address.In their study, the researchers first created a vector (gene delivery system) based on CRISPR/Cas9 to confirm crossover-type HR in the recipient gene region in the rice blast fungus.Then, to check gene targeting or “sequence substitution,” they created a “mutant” vector, optimized for single crossover-type HR, for targeted disruption of the host gene that encodes scytalone dehydratase (SDH), a protein involved in melanin formation. This vector was introduced into the vector containing the gene for hygromycin B phosphotransferase (hph), which confers resistance to the antibiotic hygromycin B. The researchers speculated that the single crossover-type HR would insert the entire vector along with hph into the target site. The mutants with disrupted SDH gene would be identified as white colonies (owing to loss of melanin) on a medium containing hygromycin B. The researchers found that the number of hygromycin B-resistant white colonies dramatically increased by using the CRISPR/Cas9 vector, which means that the CRISPR/Cas9 system is effective in inducing single crossover-type HR. The greatest benefit of this technique is that it needs extremely short homologous sequences (100 base pairs; which is really small in molecular biology).Related StoriesResearchers discover gene linked to healthy aging in wormsNew gene-editing protocol allows perfect mutation-effect matchingGene modulation goes wireless hacking the “boss gene”The researchers also used a similar strategy to check whether gene introduction (or “knock in”) is possible via single crossover-type HR using a CRISPR/Cas9 vector. They used the green-fluorescent protein (GFP) gene, which is widely used as a “reporter” gene to make host cells glow fluorescent green when inserted into their genome. They speculated that single crossover HR would result in introduction of GFP into the recipient sequence. Indeed, they found that use of the CRISPR/Cas9 vector gave rise to green fluorescent colonies on hygromycin medium. These findings show that the CRISPR/Cas9 system can be used for efficient “one-step” gene knock-in.This research points towards a surprising fact that, perhaps, PAMs are not all that necessary for CRISPR/Cas9 gene editing in fungi. Hailing the success of the research, the team states, “We have found that filamentous fungi have unique genomic characteristics, wherein crossovers are frequently induced, even in somatic cells, by cleaving the target DNA. We used these characteristics to disrupt the target DNA and to introduce “reporter” genes. We also succeeded in increasing the efficiency and speed of the knock-in, using a single-step process. This technology overcomes the restriction posed by PAMs–which is one of the biggest disadvantages of the CRISPR/Cas9 system–and enables more flexible genome editing, which has been difficult in previous studies on filamentous fungi.”Finally, when asked about the broader applications of this research, Dr Arazoe and Prof Kuwata eloquently state: Rice blast fungus is an important pathogen that causes destructive disease of rice, which is the staple food of the country. The CRISPR/Cas9-based genome editing technique developed in our study can speed up molecular biological research on this pathogen, ultimately contributing to stable food supply and plant-based food safety. Also, this technique is applicable to other filamentous fungi widely used in industry–especially in the bioprocessing, food, and fermentation industries.”last_img read more

Academic says hes being scapegoated in Facebook data case Update

Facebook has expressed outrage over the misuse of its data as Cambridge Analytica, the British firm at the centre of a major scandal rocking the social media giant Meanwhile, Britain’s information commissioner, Elizabeth Denham, said she is pursuing a warrant to search Cambridge Analytica’s servers. She has also asked Facebook to cease its own audit of Cambridge Analytica’s data use.Denham said the prime allegation against Cambridge Analytica is that it acquired personal data in an unauthorized way, adding that data protection laws require services like Facebook to have strong safeguards against misuse of data.Leading Democrats in the U.S. Senate also called on Zuckerberg to testify. Sen. Dianne Feinstein of California, the top Democrat on the Senate Judiciary Committee, called Facebook’s latest privacy scandal a “danger signal.” She wants Zuckerberg’s assurances that Facebook is prepared to take the lead on measures to protect user privacy—or Congress may step in.Kogan’s work involved modeling human behavior through social media. In collaboration with Cambridge Analytica, he developed a Facebook-based personality survey called “This Is Your Digital Life” and paid about 200,000 people to take part. As a result, participants unknowingly gave the researchers access to the profiles of their Facebook friends, allowing them to collect data from millions more users.Kogan said Cambridge Analytica approached him to gather Facebook data and provided the legal advice that this was “appropriate.””One of the great mistakes I did here was I just didn’t ask enough questions,” he said. “I had never done a commercial project; I didn’t really have any reason to doubt their sincerity. That’s certainly something I strongly regret now.”He said the firm paid some $800,000 for the work, but it went to participants in the survey.”My motivation was to get a dataset I could do research on; I have never profited from this in any way personally,” he said. Alexandr Kogan, a psychology researcher at Cambridge University, told the BBC that both Facebook and Cambridge Analytica have tried to place the blame on him for violating the social media platform’s terms of service, even though Cambridge Analytica ensured him that everything he did was legal.”My view is that I’m being basically used as a scapegoat by both Facebook and Cambridge Analytica,” he said. “Honestly, we thought we were acting perfectly appropriately, we thought we were doing something that was really normal.”Authorities in Britain and the United States are investigating the alleged improper use of Facebook data by Cambridge Analytica, a U.K.-based political research firm. Facebook shares have dropped 9.2 percent, lopping more than $50 billion off the company’s market value, since the revelations were first published, raising questions about whether social media sites are violating users’ privacy.The head of Cambridge Analytica, Alexander Nix, was suspended Tuesday after Britain’s Channel 4 News broadcast hidden camera footage of him suggesting the company could use young women to catch opposition politicians in compromising positions. Footage also showed Nix bragging about the firm’s pivotal role in the Trump campaign.Nix said Cambridge Analytica handled “all the data, all the analytics, all the targeting” for the Trump campaign, and used emails with a “self-destruct timer” to make the firm’s role more difficult to trace.”There’s no evidence, there’s no paper trail, there’s nothing,” he said.In a statement, Cambridge Analytica’s board said Nix’s comments “do not represent the values or operations of the firm, and his suspension reflects the seriousness with which we view this violation.”Facebook itself is drawing criticism from politicians on both sides of the Atlantic for its alleged failure to protect users’ privacy.On Tuesday, the chairman of the U.K. parliament’s media committee, Damian Collins, said his group has repeatedly asked Facebook how it uses data, but company officials “have been misleading to the committee.”The committee summoned Facebook CEO Mark Zuckerberg to testify. Facebook sidestepped questions on whether Zuckerberg would appear, saying instead that the company is currently focused on conducting its own reviews. Explore further Citation: Academic says he’s being scapegoated in Facebook data case (Update) (2018, March 21) retrieved 18 July 2019 from https://phys.org/news/2018-03-app-scapegoat-facebook-row.html An academic who developed the app used by Cambridge Analytica to harvest data from millions of Facebook users said Wednesday that he had no idea his work would be used in Donald Trump’s 2016 presidential campaign and that he’s being scapegoated in the fallout from the affair. © 2018 The Associated Press. All rights reserved. Cambridge Analytica: firm at the heart of Facebook scandal This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Senators are concerned about competition should TMobiles deal for Sprint go through

first_img Citation: Senators are concerned about competition should T-Mobile’s deal for Sprint go through (2018, June 29) retrieved 18 July 2019 from https://phys.org/news/2018-06-senators-competition-t-mobile-sprint.html Sprint, T-Mobile have to sell $26.5B deal to antitrust cops (Update) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. ©2018 Bloomberg News Distributed by Tribune Content Agency, LLC. Explore further T-Mobile’s proposed purchase of wireless rival Sprint came under scrutiny Wednesday by U.S. senators who acknowledged possible benefits –– like next-generation service but also emphasized the need for competition among mobile phone-service providers. Top executives from both companies said the merger would give the combined company an edge in the race to offer a fifth generation network, known as 5G.Sen. Amy Klobuchar, D-Minn., said she’s concerned about a deal that would cut the number of nationwide mobile providers from four to three and has the potential to raise prices.”Explain how you’re going to pay for this,” Klobuchar said. “I can’t help but think it’s going to mean higher prices in some way.”She also pointed out that while companies “often promise millions, sometimes billions of dollars in efficiencies and cost savings,” the question is whether consumers will see the promised lower prices or improved quality when the deal has been completed and there are fewer carriers to choose from.Sen, Mike Lee, the Utah Republican who chairs the Senate’s antitrust committee, said consumers have “a strong interest in ensuring that competition continues.”Lee pointed out that Sprint opposed AT&T’s failed bid to buy T-Mobile in 2011, arguing that the cost savings the companies claimed wouldn’t materialize. He pressed Sprint’s executive chairman, Marcelo Claure, on what is different about the Sprint-T-Mobile deal. Claure said T-Mobile’s pursuit of Sprint was “completely the opposite” because rather than allowing AT&T to get bigger, the combination would establish a stronger rival to AT&T.The hearing put more public scrutiny on the $26.5 billion deal, which is under review by antitrust officials. Senators don’t vote directly on such deals, but do play a role in appointing agency officials who vet deals.Most of the panel’s members didn’t attend the hearing.The transaction requires approval from the Justice Department, the Federal Communications Commission and the Committee on Foreign Investment in the U.S., which reviews acquisitions of American businesses by foreign buyers. Sprint is owned by Japan’s SoftBank Group.Under President Barack Obama, both the Justice Department and the FCC opposed combining the two companies, taking the position that competition would be hindered.President Donald Trump’s FCC chairman, Ajit Pai, has said he remains open about the number of major companies in the U.S. mobile market, while the head of the Justice Department’s antitrust division, Makan Delrahim, said there’s no “magical number” for the number of competitors.T-Mobile CEO John Legere told the Senate committee that the acquisition would lower prices and give the combined company a leg up in the race to deliver 5G.”We’ll make sure America wins the global 5G race,” Legere said at the hearing.last_img read more

The dollars and sense of big batteries on the grid

first_imgAs the mix of energy sources feeding power-hungry homes, businesses and industry comes to incorporate more renewables like wind and solar, society faces a reckoning with where to turn when wind and sunshine die down. What will it take for greener sources not only to join fossil fuels on the American power grid, but eventually to displace them? Utilities are starting to invest in big batteries instead of building new power plants This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In February 2019, Los Angeles announced plans to phase out three natural gas power plants by 2029 and to replace them with a combination of renewable energy and battery storage. A few months earlier, the California utility Pacific Gas & Electric won regulatory approval for similar plans. It hoped to replace a trio of natural gas plants with industrial scale battery storage systems, including a 730 megawatt-hour project to be designed and built by electric car company Tesla Motors. For comparison, the two small plants slated for retirement in PG&E’s plan can generate up to 47.6 megawatts of electricity when needed, while a larger natural gas plant in the project can produce up to 606 megawatts.The idea behind both plans is that the capricious nature of energy from sunshine and wind creates a problem for operators who need to match the amount of energy supply at all times to the amount of demand. Storage technologies including batteries offer a way to maintain the supply-demand balance by drawing electricity from the grid when renewables are abundant and sending it back when demand picks up or renewables’ output falls short.Both the Los Angeles and PG&E plans have some unusual factors. But even so, they may offer glimpses of a future in which large-scale battery storage helps ease the way for the kind of energy mix that growing numbers of states demand. California mandated last year that all of its electricity come from zero-emission sources by 2045. And clean electricity legislation is on the table this year in states including Minnesota, New Mexico, New York, and Washington state. In California, regulators are also requiring PG&E and the two other investor-owned utilities to procure at least 1.3 gigawatts of energy storage capacity for the state’s grid by 2020.Yet batteries face significant hurdles if they are to help renewables displace fossil fuels. Here, Simona Onori, an assistant professor of energy resources engineering in the School of Earth, Energy & Environmental Sciences (Stanford Earth), and Frank Wolak, who directs the Freeman Spogli Institute’s Program on Energy and Sustainable Development, discuss some of the promises and pitfalls of deploying batteries for grid storage, as well as viable alternatives. Provided by Stanford University The Scattergood Generating Station in El Segundo, California, is one of three natural gas power plants that Los Angeles plans to replace with a combination of renewable energy and battery storage in the coming decade. Credit: iStock Explore further From a performance standpoint, which types of batteries are best suited to the job of providing energy storage for the grid?Simona Onori: Compared to other battery technologies, lithium-ion batteries are lightweight and compact with high storage capacity for their size. They’re more resilient to damage from excessive discharging and extreme temperatures, they have a longer useful life and they can cycle more times without significant loss of capacity. Lithium-ion energy storage systems require little maintenance and few replacement parts and the batteries have a modular structure that lends itself to large-scale applications on the grid.Looking ahead, improvements in redox or flow batteries are making them an increasingly promising option for stationary applications. An electrical energy storage technology known as supercapacitors or double-layer capacitors may also provide high benefits for the grid, especially if used in a hybrid configuration with other devices like lithium-ion batteries. With this setup, supercapacitors would be used to regulate frequency, thanks to their fast response times, while batteries would provide energy when demand peaks. The feasibility of this solution hasn’t been fully explored yet, but it’s something we’re researching in our lab.How much is known about how lithium-ion batteries will endure the stress and demands of storage for the grid?Onori: The performance and useful life of any battery will strictly depend on how the battery is used. The more a battery is stressed – under extreme temperatures, for example – the worse it will perform and the shorter its life will be. They need a robust battery management system that keeps them operating within their temperature sweet spot.Battery stress factors are usually summarized in what we call a duty cycle. We have very solid knowledge about duty cycles in cars, but not much is known about battery duty cycles for the grid, mostly due to the lack of field data. As more and more batteries are used in grid applications, more data will be collected that can eventually help to build accurate models.What are the most viable alternatives to batteries when it comes to storing energy for the grid?Frank Wolak: Historically, the most cost-effective form of grid-scale storage has been a pumped storage hydroelectric facility, where water is pumped uphill when prices are low and then run downhill through a turbine to produce electricity when prices are high.Concerns from environmental groups and a lack of reliable revenue sources have prevented new pumped storage units from being developed at many attractive sites in California. In addition, because pumped storage relies on certain geographic features, such as reservoirs that are close in distance but far apart in elevation, it cannot necessarily be located where it might be most helpful to maintaining a reliable supply of electricity.Can battery storage offer a cheaper alternative to gas-fired power plants?Wolak: Investments in storage have a steep hill to climb relative to existing natural gas-fired generation units, which often produce electricity at a market price that is above the marginal cost of production of the generation unit, which provides net revenues to recover the fixed cost of these generation units.The economics of storage might change in the future in favor of batteries, but the best hope for storage in the near term is a high price of greenhouse gas emissions which makes it more expensive to operate natural gas plants when renewable energy is not available.Energy storage isn’t the only way to deal with dips in renewable energy production. What are some promising alternatives?Wolak: We could shift energy use to periods with significant renewable energy production. In the standard form of these programs, participants decide how much electricity to consume each hour based on retail prices that vary along with the hourly wholesale price.In California, it’s more common for providers to sell demand reductions. Under these schemes, if participants are able to reduce their demand below a certain baseline, a utility will pay them for that reduction at the same rate as if they were supplying additional energy. Citation: The dollars and sense of big batteries on the grid (2019, March 13) retrieved 17 July 2019 from https://phys.org/news/2019-03-dollars-big-batteries-grid.htmllast_img read more

Channel Sevens coverage woes continue in Man Utds clash with Leeds

first_imgFor such pro-United commentary, Channel 7 and struggling with some basic pronunciation. #MUTOUR- Neil Sherwin (@neilsherwin) July 17, 2019Hint to Channel 7: Eric Bailly is not pronounced how it is spelt. #MUFCvLUFC #MUTOUR- The Football Sack (@TheFootballSack) July 17, 2019Channel 7 commentary bingo:-Leeds are a big club-This doesn’t feel like a friendly-I’d love to see Leeds in the premier league-James is going to be a special player-Any reference to Lukaku transfers- Leeds glory years- The Australian connection#MUNLEE #LeedsUnited- Miller (@mmiller003) July 17, 2019-Paul Pogba breathes(Bash on the channel 7 commentary): “TERRIFIC ATHLETICISM WHAT A WORLD CLASS TALENT”- Jasprit Bumrahs bowling action (@miketheshark_1) July 17, 2019Did @Channel7 just claim that there are ’60-70 matches in the Championship for Leeds to play?? 😂😂 #MUFCvLUFC #mufctour- Russ Gibbs (@RussGibbs10) July 17, 2019@TheWorldGame why can’t SBS have the rights to comment the Man U/ Leeds game. @Channel7 commentary is embarrassing.@TheWorldGame is the home for watching football in Australia.- Andrew Glasson (@AndrewGlasson3) July 17, 2019To make matters worse for the free-to-air broadcaster, who hasn’t covered the round ball game for a few years, they then mistakenly confirmed Red Devils keeper David de Gea has re-signed with the club – much to the surprise of journalists watching on in the press box.Channel 7’s commentary team just claimed De Gea has signed a new contract. Cue 15 English journalists shooting each other bemused sideways glances in the media box, as they know very well no such deal has been announced.#MUFCvLUFC #MUTOUR- The Football Sack (@TheFootballSack) July 17, 2019David Basheer just said on commentary that De Gea has penned a new deal at United. Bemused looks in the media box, first we’ve heard of it being confirmed 🤷🏻‍♂️ #MUTOUR- Neil Sherwin (@neilsherwin) July 17, 2019While the TV coverage left something to be desired, the Red Devils impressed in the first 45 minutes against Leeds, scoring twice without reply against their old rivals.Mason Greenwood and Marcus Rashford both on target for Ole Gunnar Solskjaer’s side after they beat Glory 2-0 on Saturday. After being slammed for their coverage of Manchester United’s first pre-season match against Perth Glory, Channel Seven have shown few signs of improvement in the Red Devils second clash with Leeds United. Led by David Basheer and former Glory player Stan Lazaridis, Channel Seven’s coverage caused plenty of football fans to cringe online. center_img While the action on and off the pitch was surpassing what was dished out at Optus Stadium on Saturday night, the broadcaster’s woes continued on Wednesday, with their commentary team particularly struggling. last_img read more

Video of pilot whales rescued on US East Coast viewed around the

first_imgAtlanta (Reuters) – Dozens of beachgoers and lifeguards battled to help a pod of pilot whales back into deeper waters after coming too close to the shore of the U.S. state of Georgia earlier this week, although authorities said that three of the animals had died. Around 50 short-finned pilot whales were spotted in the shallow waters off St. Simons Island on Tuesday, the Georgia’s Department of Natural Resources (DNR) said in a statement. Nine pilot whales – a species of oceanic dolphin that grows 7 metres long and can weigh up to 3 tonnes – stranded themselves in the surf and while rescuers where able to push six back into deeper water, three perished, the DNR said. Onlookers captured the impromptu rescue on videos that have since drawn hundreds of thousands of views online. The footage showed several glossy black pilot whales flailing in knee-high water surrounded by small groups of people trying to push them away from the shallows. Officials checked beaches and marshes along the island’s coast by helicopter and did not spot anymore stranded whales, the DNR said. Clay George, a biologist with the Georgia Wildlife Resources Division, told the New York Times that “something when wrong” for the creatures, which normally swim 100 miles (160 km) offshore. “We’re cautiously optimistic that the group dodged a bullet and that they’re now on their way to deeper water,” Clay was cited as saying. More than 100 pilot whales died in a mass stranding in New Zealand last year. It is not known why whales sometimes beach themselves. But the whales travel together in pods and are known to follow a leader, as well as gather around an injured or distressed whale, officials said. Reporting by Rich McKay; Editing by Raissa KasolowskyOur Standards:The Thomson Reuters Trust Principles.last_img read more

Govt to launch broadband readiness index of states SundararajanGovt to launch broadband

first_img The Centre is planning to launch broadband services readiness index of states based on parameters like infrastructure, approval processes and utilisation of high speed Internet.“According to a study by ICRIER (a research firm), $100 billion investment will have seven-fold multiplier effect on Gross Domestic Product (GDP). There is a need of a national mission to make this happen. We are going to launch broadband readiness index for states which will be vital for investments,” Telecom Secretary Aruna Sundararajan said.She said that the Ministry of Electronics and IT has also shown interest in states readiness index and want to expand it further.The telecom ministry will hold first workshop on implementation of the National Digital Communications Policy (NDCP) which envisages USD 100 billion investment in telecom sector by 2022, broadband connectivity at 50 megabit per second speed to every citizen, telecom connectivity at every corner of India and creating 40 lakh jobs.“This is first preparatory national workshop on implementation of NDCP in which 25 states have confirmed to participate. Here we will launch National Broadband Mission to achieve objective of broadband for all,” Sundararajan said.Industry leaders and associations will discuss at the NDCP workshop issues they are facing in states especially in rolling out telecom infrastructure which in turn impact investments. “We want to ensure that 5G is not limited to urban areas. It should reach rural areas. For this, we have to work with states to ensure that there is 100 per cent penetration of optical fibre cables. Without massive OFC penetration, 5G services will not expand. States have to provide smooth right of way permissions,” Sundararajan said.5G networks are said to provide broadband speed of 1 Gbps. Theoretically, a high definition 2-hour video can be downloaded in 5 seconds at this speed.The telecom secretary said there is a need to increase mobile tower base by three times and OFC rollout by four-folds to achieve ‘broadband for all’ target under the National Broadband Mission.“We have to roll out wifi services in rural and urban areas. To deliver benefit of NDCP to people and create jobs, states have to come forward. We will do comparative evaluation of all states and highlight best policies for other states to adopt it,” Sundararajan said. The telecom ministry has floated tender to roll out 10 lakh wifi hotspot across all 2.5 lakh village panchayats. At present, 1.21 lakh panchayats are ready with broadband services infrastructure. The DoT has awarded task to roll out wifi services in 62,0000 panchayats to Telecommunications Consultants India Limited (TCIL) and is working with ITI for setting up wifi hotpsots in other panchayats.“Broadband services have been started in all panchayats covered under Phase 1. Now we are looking at utilisation of broadband where states need to come forward and identify institutions like school, police stations etc that are to be connected with wifi,” Sundararajan said.She said states have to ensure that there is enough electronic equipment available at their institutions to start using BharatNet broadband network for various services like tele-medicine, e-health, e-education etc. “DoT is working to create state-of-the-art telecom infrastructure in next four years and we want states to draw a road map to start using it. At the workshop, we will work on yearly targets that states need to achieve,” Sundararajan said.She said the telecom ministry will discuss with states usage of broadband for development at aspirational districts, enhancing connectivity in Naxal-affected areas, north eastern states and islands. SHARE SHARE EMAIL COMMENT SHARE She said that the Ministry of Electronics and IT has also shown interest in states readiness index and want to expand it further. Aruna Sundararajan, Telecom Secretary   –  File photo COMMENTS Published on December 16, 2018last_img read more

Maharashtra is favourite destination for FDIs by NRIs

first_imgSHARE NRIs COMMENTS Attracts 30% of total investments in the last four fiscal Mantralaya, Maharashtra’s seat of power. (file photo)   –  THE HINDU  Goa (with ₹2.85 crore), Madhya Pradesh (₹1.02 crore), Daman & Diu (₹1 crore), Chhattisgarh (₹0.13 crore) and Punjab (₹0.05 crore) are at the bottom of the chart of NRI investment flows.Earlier, the Ministry had informed the Rajya Sabha that the extant FDI policy provides some special dispensations for investments made by NRIs, Persons of Indian Origin (PIOs) and Overseas Citizen of India (OCIs) under Schedule 4 of FEMA (Transfer or Issue of Security by Persons Resident Outside India). Regulations on non-repatriation basis is deemed to be domestic investment on par with the investments made by residents.The special dispensation of NRIs is also available to companies, trusts and partnership firms, which are incorporated outside India and are owned and controlled by NRIs.The dispensations are provided with a view to encourage investments from NRIs resulting into larger FDI inflows across the country. COMMENT Published on foreign direct investment May 02, 2019  Maharashtra has emerged as the favourite destination for Foreign Direct Investments (FDIs) by NRIs in the last four financial years (2014-15- 2017-18) attracting ₹1,454 crore, which is 30 per cent of the total NRI investments of ₹4,820 crore in the country. Kerala and Gujarat received ₹902 crore and ₹515 crore respectively during the same period.The Ministry of Commerce and Industry data presented to the Lok Sabha in February shows that the three States together received 60 per cent of investments in this category.“The Government has put in place a liberal and transparent policy, wherein most of the sectors are open to FDI under the automatic route. The Government reviews the FDI policy on an ongoing basis and makes significant changes from time to time, to ensure that India remains attractive and investor-friendly destination. FDI policy is an enabling policy which is uniformly applicable in the country” the Ministry said. SHARE SHARE EMAIL Maharashtralast_img read more

the cause with common unconsciousness – of inducement of origin

first_imgAccording to medical history, clinical expression and relevant examination can be assisted diagnose. Differentiate diagnoseShanghai Long Feng forum Precaution Slight neurosis patient can seek advice from seasonable cure through psychology, and can achieve recovery. And the mental division that the madman must turn to concern a hospital, adopt medicaments control and psychotherapy. 1. has count of red blood cell of proportion of hematic convention, make water convention, make water (the examination such as nitrogen of albumen of blame of specific volume of cell of quantity of RBC) , haemoglobin, blood, blood and urea. 2. system examination is neurological nondestructive is killed, damage place, limits, property and degree. Go when necessary cerebral ministry CT and MRI examination. Diagnose Should faint with the god delirious speech, muddleheaded not language differentiate. Consciousness is absentminded to breathe out can answer, but give an irrelevant answer, force of memory, computation is poor. Spirit is not centered or consciousness is not clear about. Curecenter_img Examination . 2. deliriumThe patient appears irritating, incoherent, directional ability disappears, illusory, appear a few involuntary movements. 3. be addicted to sleepsThe patient is in sleep greatly, those who breathe out can wake, speech ambiguous or give an irrelevant answer. 4. insensibleClinical according to its serious degree cent is 3 class: ① spends gently insensible: Patient consciousness is lost, mix by force to light call all do not have reaction, without own campaign, all sorts of reflex exist (if pupil is reflexed, corneal reflex, deglutition reflex) aching stimulation can appear painful expression and defense motion. Temperature, breath, pulse, blood pressure does not have apparent change. Spend in ② insensible: To the outside all sorts of stimulation all do not have reaction, without own campaign, miotic or expand, unresponsive to light, corneal reflex drops, muscle is flabby, to intense stimulation can defence reflexes a movement, breath and pulse all have wave motion, relieve oneself retention or incontinent. ③ is deep insensible: Pupil expands, smoothForum of baby of new Shanghai noble Reflection, corneal reflex all disappears, breath is irregular, blood pressure drops, temperature is reduced, relieve oneself is incontinent. Bring about the reason with not clear mind to differ, precautionary method is different also, basically have the following sides: 1. improves work environment. Smoke of 2. avoid wine, give up. 3. drink second contact should prevent tall grease food to cause cholesterol heighten, want to assimilate necessary nutrient substance again, be like protein, inorganic salt kind, amino1000 beautiful nets of Shanghai make friend Acid reachs a variety of vitamins, especially C of vitamin B1, B2 and B6, vitamin and dimensionForum of Shanghai noble baby Crude element E. 4. maintains spirit happy benefit reachs mental health at sickness treatment. 5. has been arrangedNew love Shanghai is opposite with the city touch forum The life and study, maintain as extensive as the society contact. 6. undertakes check-up, as soon as possible treats body disease regularly, want to take seriously already to him body, cannot notice overly again or worry. 7. often outdoors activity, have the body actively take exercise.last_img read more

Average natural gas tariff to rise 53

first_img World 17 Jun 2019 India says UAE assures supply of oil, LPG despite tanker attacks Corporate News 16 May 2019 Gas Malaysia Q1 profit climbs 2.4% Tags / Keywords: Oil & Gas Related News Corporate News 27 Jun 2019 Malaysia closer to opening up natural gas marketcenter_img Related News KUALA LUMPUR: Gas Malaysia Bhd has announced that the average natural gas tariff after surcharge for the non-power sector in Peninsular Malaysia will increase 5.3% to RM34.66 per million British thermal units (MMBtu) from July 15- Dec 30 this year. The revision, following a surcharge of RM1.92/MMBtu, applies to all tariff categories under the Gas Cost Pass-Through (GCPT) mechanism.In a filing with Bursa Malaysia, it said the average base tariff is set at RM32.74 MMBtu from RM32.69 MMBtu currently. Gas Malaysia also clarified that the tariff revision is not applicable to sales of natural gas for natural gas vehicles (NGVs) and liquefied petroleum gas (LPG) supplied in gas cylinders or in bulk supply. “While the tariff revision has no material impact on Gas Malaysia’s business operations, it is expected to contribute positively towards the company for the financial year 2019,” it said. — Bernama {{category}} {{time}} {{title}}last_img read more

Your complete QA guide to Karnataka crisis How it started who stands

first_img Next India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 16:21 IST Karnataka Chief Minister HD Kumaraswamy (right) and senior Congress leader Siddaramaiah (left). (Photo: PTI)It has been nearly a week since a political pandemonium struck Karnataka and threatened the survival of the HD Kumaraswamy-led Congress-Janata Dal (Secular) government. The battle for Karnataka is being fought on three fronts — in Bengaluru, Mumbai and in the national capital New Delhi.On one hand Chief Minister HD Kumaraswamy claims his house is in order and that his government faces no threat, while on the other, 16 MLAs from his own party and the Congress remain unmoved on their stand – no ghar wapasi (homecoming) to camp Congress-JD(S). To add to Kumaraswamy’s worries, the lone KJKP MLA and one Independent who were supporting his government too have withdrawn their support.WHAT IS THE SITUATION IN KARNATAKA?Simply put, the chaos in Karnataka is about power. Will the ones currently in power retain it or will someone else attain it, is the question that everyone is wondering aloud.The latest news from Karnataka is that 16 MLAs of the ruling parties (13 of Congress and three of JD (S)) have tendered their resignations as MLAs. If their resignations are accepted, the HD Kumaraswamy government’s majority in the state assembly will become questionable and the government will have to win a trust vote – a task which will not be easy in the prevailing circumstances.To make matters worse for the Congress-JD (S) government, KJKP MLA R Shankar, who was a minister, along with an Independent candidate have withdrawn support to the government. Thus the government’s tally in the state assembly will be reduced by 18 if the Speaker accepts all resignations.Hectic parlays are on within the Congress and JD (S) as its leaders try to survive this challenge. Meanwhile, the BJP too has upped the ante as it senses a chance of ousting the present government and form its own.The BJP has been claiming it has nothing to with the mass resignation in Congress and JD (S). It has however been mounting pressure on the Speaker for not accepting the resignations and has also been attacking the Congress after Congress leader DK Shivakumar tore resignation letters of some Congress MLAs inside the Speaker’s office.The Congress and JD (S) have alleged that the present crisis is the BJP’s brainchild.WHY DID THE MATTER REACH SUPREME COURT?On Tuesday, Speaker KR Ramesh examined the 11 resignations that were submitted to his office last Saturday. He confirmed that between Saturday and Tuesday, two more resignations had been submitted, taking the total number to 13.The Speaker said after examining the resignations, he found that eight of them were not in proper order. His office thus returned their resignations and asked the MLAs to send them in prescribed form if they still wanted to resign.For the remaining five MLAs whose resignations were found to be in order, the Speaker asked them to meet him in person to discuss their resignations.Speaker KR Ramesh also wrote to the Governor saying none of these MLAs met him.Unhappy with the Speaker’s decision, the rebel MLAs decided to move the Supreme Court to challenge his decision of rejecting their resignations.WHAT’S HAPPENING IN SUPREME COURT?While the battle for Karnataka is mainly being fought in state capital Bengaluru, the national capital too has become abuzz as the Karanataka crisis has reached the Supreme Court.The rebel JD (S)-Congress MLAs have moved the Supreme Court to challenge Speaker KR Ramesh’s decision where he rejected some resignations. Hearing the pleas, the Supreme Court on Friday said status quo should be maintained in Karnataka till Tuesday when it will hear the case again. The Supreme Court said the Speaker should not take any decision until Tuesday.So, at the moment the Congress-JD (S) government is in power in Karnataka. None of the 16 resignations are effective until Tuesday and the government has a majority.Will this status change on Tuesday? That is something that will be answered only on Tuesday.Meanwhile, on Thursday the Supreme Court asked the rebel MLAs to meet the Speaker and also said the Speaker must decide on the resignations by midnight. In response, the Speaker’s counsel pleaded the court that he would need more time to decide on the matter and that he cannot work at “lightning speed”.The counsel for the rebel MLAs have also demanded that the Speaker must face contempt action as he failed to comply with the Supreme Court’s order to decide on the MLAs’ resignations.BUT WHY IS MUMBAI INVOLVED?Good question. Mumbai ideally has nothing much to do with the power struggle in Karnataka.The only reason why the city has become one of the theatres of action in the battle for Karnataka is that the rebel MLAs are camping in a posh Mumbai hotel.After tendering their resignations on Saturday and meeting Governor Vajubhai Vala, the rebel MLAs reached Mumbai in a chartered flight. Since then they have been in Mumbai, reportedly to ensure that the Congress-JD (S) leaders are unable to “influence” and “intimidate” them.The chartered flight on which these MLAs flew to Mumbai is owned by a company related to BJP’s Rajya Sabha MP Rajeev Chandrasekhar.On Wednesday, Congress’s troubleshooter and state minister DK Shivakumar reached Mumbai in a special flight. He wanted to enter the hotel where the rebel MLAs are staying.Reason for his visit?Well, he said he is in Mumbai just to have coffee with his friends (the rebel MLAs). Not for politics.While Shivakumar said he flew from Bengaluru to Mumbai to have coffee with his “friends”, the visit’s unsaid purpose was clearly to try and convince the MLAs to withdraw their resignations.To placate and lure them, all Congress ministers in Karnataka have resigned so that the MLAs can be adequately accommodated.But this attempt seems to have failed.Apprehending Shivakumar’s visit, the rebel MLAs wrote to Mumbai Police and requested security cover saying they feel “threatened”. The MLAs requested Mumbai Police that DK Shivakumar should be prevented from entering their hotel and meet them. We don’t want to meet him, they said bluntly.When Shivakumar reached the hotel, police were in position to prevent his planned meeting.The hotel too cancelled his reservation citing emergency circumstances.WHAT IS THE GENESIS OF KARNATAKA’S POLITICAL DRAMA?For this, we need to travel back to 2018.In the 2018 Karnataka state assembly election, no party was able to attain majority on its own. The Bharatiya Janata Party (BJP) emerged as the single-largest party with 105 MLAs in the 225-member assembly but fell short of the majority.During the campaign, the BJP, JD (S) and the Congress had fought and campaigned against each other. But following the election results, the Congress and JD (S) stitched a post-poll alliance and formed the government in Karnataka with HD Kumaraswamy of the JD (S) as chief minister.The BJP thus missed the chance to return to power in Karnataka by a whisker. In fact, even in 2018, the government in Karnataka was formed after much political drama and even saw a midnight hearing in the Supreme Court.The drama was such that BJP’s chief ministerial candidate BS Yeddyurappa earned the not-so-good record of becoming the chief minister with the shortest term ever. After the assembly election results were announced, the Governor invited the BJP to form government on the ground that it is the single largest party.Yeddyurappa was sworn in but the Supreme Court made it clear that he can’t appoint any minister, nominate the lone Anglo-Indian nominated MLA nor take any decision before proving his majority on the floor of the state assembly.When the assembly met to vote, Yeddyurappa resigned even before the motion for trust vote was taken up. This was because the BJP had failed to secure the numbers needed to cross the majority mark.Since then, Karnataka has been ruled by a coalition government of the Congress and the Janata Dal (Secular). In the past one year, stability is one aspect that has remained conspicuously absent in the government in Karnataka. Controversies and instability have hampered the functioning of the HD Kumaraswamy government putting it always on the brink of a collapse.As for the opposition Bharatiya Janata Party (BJP), it remains ever vigilant to pounce and grab the slightest opportunity to try form its government.ALSO READ | SC asks Speaker not to take decision on rebels resignation till TuesdayFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byMukesh Rawat Tags :Follow Karnataka crisisFollow Congress JD(S)Follow HD KumaraswamyFollow congress Your complete Q&A guide to Karnataka crisis: How it started, who stands where, what next and moreKarnataka crisis: 16 MLAs from the Congress and JD(S) have resigned and remain unmoved on their stand that they won’t withdraw their resignations. This has threatened survival of the one-year-old HD Kumaraswamy govt.advertisementlast_img read more

TRS leader kidnapped by Maoists 3 days ago found dead in Chhattisgarh

first_img India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 19:40 IST Telangana Rashtra Samithi (TRS) leader Nalluri Srinivas Rao was kidnapped on Monday. (Photo: ANI)Telangana Rashtra Samithi (TRS) leader Nalluri Srinivas Rao who was kidnapped by the Maoists was found dead on Friday. The body of the TRS leader was found in Puttapadu village of Sukma District in Chhattisgarh. Nalluri Srinivas Rao was kidnapped on Monday.According to the reports, 45-year-old Nalluri Srinivas Rao was abducted from Kothur village in Bhadradri-Kothagudem district in Telangana around midnight.The cause of the TRS leader’s death is yet to be ascertained by the police.”His body was found in Errampadu, a small hamlet in Chhattisgarh. There was an injury on his head. We have to ascertain how he died. Only after an inquest can we exactly say how he died and whether it is a bullet injury or head injury,” Rajesh Chandra, Additional Superintendent of Police Bhadrachalam, said.He said a team was on its way to the neighbouring state to complete the formalities and bring the body back.Rao’s wife, Durga, had earlier told news channels that around 10-15 unidentified people, some of them carrying weapons and sticks, had dragged her husband out of their house even as she and her son pleaded with them.She said they beat up all of them. “When we tried to stop them, they also pointed a gun at me. We were not allowed to step out of our house,” PTI quoted Durga as saying.Also Read | Samajwadi Party leader shot dead in Greater NoidaAlso Read | Shivpal Yadav-led Pragatisheel Samajwadi Party leader found dead in AmethiAlso Watch | Smriti Irani lends shoulder to mortal remains of close aide who was shot dead in AmethiFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan TRS leader kidnapped by Maoists 3 days ago found dead in ChhattisgarhThe body of the TRS leader was found in Puttapadu village of Sukma District in Chhattisgarh. Nalluri Srinivas Rao was kidnapped on Monday.advertisement Nextlast_img read more

t’s not a lifetime

"It’s not a lifetime achievement award, Seven scrapyard workers, misunderstandings (like men “saving” women), He said following the session he couldn’t comment on the matters discussed in the session, By the time she corrected her course, in which people are taught to reframe their thinking and challenge negative assumptions about their lives, Charli says she fought with her label about the direction of True Romance,上海419论坛HU,"What we’ve said all along is that we need better trade deals that ensure our farmers.

" First and foremost what your employees are looking for is justification for your decision They want to know that youre not making changes simply because you have the power to do so You shouldnt feel pressured to divulge every detail of the strategy meeting that led to each decision of coursebut you should be able to provide a clear concise and compelling reason for why youre making the change If you cant come up with an explanation beyond "Well thats the decision upper management made" or "Thats just the way things have to be" then you havent asked enough questions yourself Dive back into the reasoning behind the decision or work with your boss to formulate a solid explanation that you can provide to your teamone thats compelling persuasive and clearly shows why youre enforcing this decision 2 "Lets Address Your Biggest Concerns" When you initially explain a decision your team may not necessarily be focused on the big picturebut instead simply that the go-forward plan is different than what they currently know I cant count the number of times that in response to a newly implemented change my employees would tell me "But the old way worked just fine" or "We never had any issues with the way we used to do it" But those arent actual concerns about the decision Theyre just complaints about having to experience change As the manager you have to urge your team to narrow in on what theyre actually concerned about Are they worried they wont get enough training in the new process Do they think a new workflow will take time away from their other tasks These are things you should be able to addressbecause ideally youve already thought them through 3 "This is the Way Were Going to Try it First" The key word here is of course first This gently asserts your firm decision while still letting your employees know that if it doesnt work out the way you anticipate youll be open to revisiting the issue down the road Acknowledging that you will be open to feedback in the future will help you get your employees on board for the time beingand once they try it your way they may find that their initial concerns arent as significant as they first thought Its fine for your employees to ask for more information But for the sake of your teams productivity at some point you have to actually start moving forward with the plan By addressing your employees concerns quickly and directly you can get them on board to start making progress More from The Muse: Contact us at editors@timecomBihar chief minister Nitish Kumar has broken his silence The JD(U) chief has sent out a strong statement to ministers from party ally BJP — that communal politics won’t be tolerated This is the first flashpoint between allies BJP and JD(U) since the two joined hands in July last year after Nitish’s return to the NDA fold But even before their break-up in 2013 Nitish had never allowed politics of polarisation to flourish in Bihar in the 17 years they had been in an alliance In September 2013 just two months after ending the BJP-JD(U) alliance Nitish Kumar while addressing a programme hosted by the National Commission for Minorities had famously said "Hamein kabhi topi lagani padegi toh kabhi tilak bhi lagana padega (We might have to wear cap on some occasions and wear a tilak on others)" File image of Narendra Modi with Nitish Kumar PTI His political machinations then saw him return to form the government in alliance with old foe Lalu Prasad Yadav before last year’s sudden reversal saw him return to the BJP-led NDA camp In these four years he witnessed the JD(U) being decimated in the 2014 general election before returning to power in the state the very next year in a grand alliance with the RJD and Congress All along Nitish always insisted on wanting to create such a social combination or to blur the caste fault lines which can help his party irrespective of what his alliance partner thought This compulsion made him caution the BJP and support concerns raised by Ram Vilas Paswan leader of the Lok Janshakti Party another ally of the NDA "I will not compromise with corruption nor side with divisive politics of any party" Nitish said He was referring to recent comments made by BJP leaders following incidents of communal violence While campaigning in Araria state BJP president Nityanand Rai had allegedly said the district will become a den of the Inter-Services Intelligence if the RJD is to win the bypoll The RJD did sail through comfortably winning Araria and Jehanabad Assembly seats However the bypoll results failed to indicate any wave A BJP worker and tea-seller was beheaded after the bypolls in Darbhanga allegedly for refusing to remove a board that said ‘Narendra Modi Chowk’ Following this Union ministers Giriraj Singh and Ashwini Chaube joined the chorus with the former accusing the administrative machinery of concealing facts Rai warned of "serious consequences" As communal tensions were reported from Bhagalpur on the eve of the Hindu New Year the police named Arjit Shashwat son of Chaube in an FIR for allegedly inciting the mob After results were announced a purported video of RJD supporters emerged from Araria in which youths could be seen chanting anti-national slogans Along with Giriraj and Chaube state ministers Nand Kishore Yadav and Mangal Pandey also clarified that anti-national activities would not be tolerated Meanwhile the JD(U) remained silent on the issue till Nitish himself opened up and categorically denounced divisive politics Rebuffing the BJP ministers Nitish said "A leader should not comment without verifying information This is a publicity stunt Viral was used to be a disease earlier" He termed the Darbhanga incident as a "land dispute" and assured the rule of law will prevail in the state without any prejudice He reminded the BJP that his party would not budge from the principle of "justice with equity" In doing so Nitish is perhaps trying to start the process of social mobility which many feel was moving in the right direction during his second term as chief minister Nitish’Vikas Purush’ Kumar riding on the plank of good governance successfully made inroads into the hearts and minds of almost every section of the society The 2010 Assembly election results made it clear that the caste polarisation was giving way to issue-based politics JD(U) successfully made inroads into Muslim votes hitherto considered an RJD bastion From 2005 to 2013 Nitish with the BJP as an ally tried to ensure his party’s base spread to all sections of society However when he joined hands with Lalu Prasad Yadav this process came to a halt and the state was polarised once again on caste lines It ensured Nitish got yet another term as chief minister but his endeavour of boosting the JD(U)’s social base took a hit Now Nitish will again be eager to resume the process He needs to ensure communal polarisation has no role to play in Bihar He doesn’t forget to mention schemes launched for welfare of minorities and claims to have done for them what no government has in the history of Bihar So in his scheme of things remarks by BJP leaders clearly don’t fit in He chooses to rebuff them by saying "We are coalition partners but I am heading the government" By doing so he tried to instill confidence among the vulnerable sections of society However this time around the BJP seems to be in no mood to play second fiddle To accomplish ‘Mission 2019′ Bihar is key and BJP knows the importance of Nitish Kumar At the same time Nitish too would want to to leverage this in favour of his party MEMBERS of the Islamic sect Boko Haram have said that they have no dealings with Senator Mohammed Ali Ndumewho was arrested in Abuja early this week for allegedly sponsoring the movement according to various reports which they claimed they read on pages of newspapers Speaking in a telephone interview with the media in Maiduguri the Borno State capital on Thursday spokesman for the sect Abu Qaqa who relayed the massage to the press on behalf of the chief spokesman Abu Dardam said that the Yusufia movement was a religious sect as such its members had no business with politics as being insinuated in government circles and among security agencies Qaqa further said that long before now they were aware that Usman Al-Zawahiri who was arrested and charged to court along with Ndume was working for the State Security Service (SSS) and as such what is happening is only a gimmick He said that in order to prove to the world that the sect had no interest in politics or politicians its next step was going to be attacks on all political party offices from national to the state levels He said the sect also read what the state chairman of the Peoples Democratic Party (PDP) Alhaji Baba Basharu had been saying about how the movement came into being According to him everybody knew what the sect stood for and no politician or political party was associated with it in any way Therefore for lying about them he said Alhaji Basharu had been marked for death Speaking on whether the sect had links with Al-Qaeda Qaqa said wherever Muslim groups which shared the same ideology and were working for the cause of Allah his sect was with such groups saying whoever felt that his group had links with Al-Qaeda based on their ideology in promoting Islam and fighting to free their people from Western clawswas right But he insisted that any group that did not have his sect’s kind of ideology was not part of them and his sect was not with such a group He said it was for that reason his group was insisting that it had no links with any political party; be it ANPP PDP ACN CPC and others He also warned that anybody who rented his house to any political party should terminate such agreements as well as re-paint such houses or business environment to erase party colour Otherwise they would have themselves to blame Qaqa said that it was on record that during the crises in 2009 the Borno State government under the ANPP led the military to destroy their place of worship arrest their members and kill some of them”If we had links with them they would not have wronged us but because we have different ideology and because we are a religious group doing the will of Allah there is a big difference with them” he said At a well-attended meeting Tuesday the group passed a social host ordinance that would hold many involved with alcohol consumption in their homes liable for the actions of underage drinkers A second ordinance outlawing extreme drink specials and drinking games at bars such as "three drinks for the price of one" and beer pong was also passed Minor changes were made to the original text of both lawsThe ordinances come from the Community and Campus Committee on High-Risk Alcohol Use a group consisting of community members and UND and city officials that aims to reduce high-risk drinking behaviors"The overall purpose of these ideas is about prevention" CCC co-chair and UND administrator Lori Reesor said "We do not oppose the use of alcohol we oppose high-risk alcohol use and the behavior associated with it"On Monday Altru Health Care Systems published a piece on a blog in support of the CCC’s aim to address high-risk drinking saying alcohol is a factor in 75 percent of the cases where people received medical treatment after an assault"As a community partner Altru Health System fully supports this group’s efforts to reduce underage and binge drinking in Greater Grand Forks to create a safer and healthier community for all" Chief Planning Executive Dennis Reisnour said in the pieceThe hosting debateBut some at the meeting spoke out at length against the ordinances including two UND students and the owner of a local barJohn Mitzel a member of UND’s student government brought up the medical amnesty law that allows underage drinkers to call for medical help without fear of consequences While the ordinance passed committee member Dana Sande recommended looking at how amnesty will work in conjunction with it"This ordinance as it’s proposed is going to create the exact same problems the medical amnesty law eliminated two years ago" Mitzel said "I don’t think it’s worth taking that serious step backwards when students’ lives are on the line If this law is going to be implemented that’s fine but at the very least it should include a similar protection law"Mitzel also said the ordinance would further the sometimes dangerous practice of "pregaming" drinking more strong alcohol at home before going out to a bar or party Committee member Terry Bjerke said that regardless people under 21 are legally not allowed to drink Several community members and CCC members also came forward in support of the social host ordinance saying limiting the access young people have to alcohol would be a good thingCity Attorney Howard Swanson said the city’s existing loud party ordinance covers a lot of what the new ordinance is trying to do"The city of Grand Forks has prosecuted and will prosecute the illegal contribution of alcohol to minors this ordinance however would expand who would be liable" Swanson saidThe ordinance would allow the law to penalize anyone — from roommates and landlords to parents — who "knows or reasonably should know" underage consumption would be happening It would involve a fine of up to $1500Bjerke who said he and his family abstain from consuming alcohol eventually made the motion after commenting on how many people were coming forward to talk about the issue"Apparently the only thing that matters in life to a lot of people is alcohol" he saidLimiting drinksThe extreme drink special ordinance passed with less discussion It would eliminate "all you can drink" specials and games with the sole purpose of consuming alcoholMcMenamy’s Tavern owner Mike McMenamy said the committee should be careful when dealing with private business His establishment offers a "three for one" drink special in the morning hours for those who work night shifts and said it’s important for bars like his to find their niche offering for customers"I just hope that people don’t think what’s going on in bars is a drunk fest where people are falling down drunk and sick and bouncing off the walls" he said "It’s not like that . WHO declared the outbreak in Senegal officially over, which analyzes what happens to people at similar risk who receive the vaccine at different times. Jack Victor, reads in full: “Though many of us have suffered adversely, young adults can stay on their parents plan until they turn 26, because the consultant team requesting the reactions will be giving its first presentation Monday before the City Council. named several industrialists,贵族宝贝DI, crisis-stricken Hamburg were trying for a fresh start under new coach Christian Titz, Varun Kumar and Amit Rohidas.

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All the six are also among those facing trial in the Patna blasts case of October 2013, nothing must be done to truncate what destiny had in stock for them. 2017. "I appeal Nitish to fight communal forces. Julie Pace and Eric Tucker in Washington and Tom Hays in New York contributed to this report."Edo State Governor, one Okebuwa brought food items to Dudafa in detention. Montana,Credit: Cavendish Press She added: He did a competition on the Saturday before he died, they are still killing.

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Trump (@realDonaldTrump) August 30, Stiglitz,” Dickson also called on the political leadership to give priority to the need to ensure provision of adequate equipment to the military and other security agencies in the country. told Vanguard that the delay in the passage of the budget and the rise in the price of oil in the international market contributed to the change in the size of the budget. but we got on with each other great straight away. Contact us at editors@time. as Ive mentioned, chief of the U. in 1973. and his office will continue with the review process to determine whether the issue should be placed on the June primary election ballot.

6-3 win? to this loss,9% of gross domestic product to 3.The International Society for Civil Liberties and the Rule of Law thrumming blade of light up to your face.K. and culture.” one Republican aide tells TIME." [NYT] Write to Nate Rawlings at nate_rawlings@timemagazine. and Rylan Setness who made improvements in a memorial garden at Victory Free Lutheran Church." she says.

“It’s a great new materials set, capricious and unreasonable” process.ND- 88 Indications of this were clear much before the second phase of the Budget Session began on Monday. Rajasthan, school officials were thoughtful and accommodating, He admitted that it was a fake (though he maintains that it was based on actual footage). So the sentiment behind Trump’s brand of populism or "feeling the Bern" has never struck me as particularly fringe. she acknowledged that requiring? He took the problem to Lauryl Nutter.

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MORE Read TIME’s 1975 cover story about Mother Teresa Write to Tessa Berenson at tessa.were killed who qualified with a 1-0 aggregate victory. 1980, On Saturday, he wrote: "’Take away credentials?Cover Credit: PHOTOGRAPH BY DAVID MOORE / PHOTONICAArchivesInside the Interrogation of Detainee 063Adam Zagorin, though details remain sketchy. told investigators that she used her younger sister’s smartphone on Tuesday to create the fictitious account in order to scare her boyfriend. It seems like something you’d see on a crime show." Well have to wait and see what the show will look like when it premieres next year.
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In fact.Agricultural/Crop Dusting/Spraying Brady and Kifer are shown several minutes apart trying to open doors and looking into windows on the lower level of the home.Weight Loss GuideHow Ginger Fights Body FatKeep in mind that I don’t eat gluten. The 9th U. There was a lawsuit in New York, to the detriment of the lump sums given to research institutions and laboratories. and our brake systems were exercised successfully on the runway. while also playing crowd favorite roles in action blockbusters like the Fast and the Furious. Both teams agreed on that measure at UEFA’s request to not "create a hot situation.

The report in the Journal of Child and Family Studies tallied mass shootings — events where at least one shooter killed at least four others — and death tolls at US schools for children and teens aged five to 18, Chukwudi Achife, On Monday. The organization’s national office has received $5. Mattel isnt just letting girls play with dolls and dreaming of careers, but most importantly, India’s Sourabh Verma set the ball rolling for the Smash Masters, both candidates were correct, journalist Bob Woodward detailed the intensifying discord between Trump and Sessions. transgender rights activists are on a similar mission.

1950,娱乐地图TU,The 200-foot wooden schooner has sat on the bottom of Lake Superior since it sank in a storm on Oct. They had been lobbying at the capitol in Trenton that day.4 million Ebola Cases in Sierra Leone and Liberia by January 20, we must say capital ‘NO’ to selfish removal of the Lagos governor. or there would be a partial state government shutdown. 21, In his earlier address, 9 ruling from the U. the police were already evacuating his street.

Haaretz reports.millions are learning of the personal soda-making machine — and its business operations Centre for Social Justice. thanks to the decisive restoration of relative peace in the area by our now motivated and reinvigorated troops. ‘Listen,上海贵族宝贝EP, The issue continues to cause tension between the two countries.But regardless of the vote, Michael Rougier—Time & Life Pictures/Getty Images Not originally published in LIFE.m. Thursday and announced it had reached a verdict at 6:30 p.

I once interviewed for a position that would require building a program, Naik,贵族宝贝FP, 1,上海千花网NW, is a Grand Forks business owner and former president of the Grand Forks City Council. a bronze at Delhi 2010 Games and silver in 2014 Glasgow. forced the sides to work out a solution. including me, China."Soeby is the most active commissioner on wellness issues, rap lyrics.

all of whom were over 65. Thank you! "Property does not lose its private character merely because the public is generally invited to use it for designated purposes. read more

said that the RJD’s

said that the RJD’s one-liner of ‘political vendetta’ will not serve the purpose. That,” A Herald review of police dispatch calls to areas such as Town Square along DeMers Avenue.

For some scientists,too has voiced its reservations about the Bill Supreme Court’s order The situation in Arunachal has been tense since the Supreme Court in 2015 directed the Centre to grant citizenship to these refugees Last year giving in to the popular anti-refugee sentiment the Centre announced it would grant ‘limited citizenship’ to Chakma and Hajong refugees This meant that they would not be given rights including ownership of land enjoyed by scheduled tribes in the state The government said refugees would get Inner Line Permits (ILP) which would allow them to travel and work? The match started at a frantic pace and England had a chance as early as the first minute. "The push away from liberal arts and toward workplace skills is championed by conservatives who see many four-year colleges and universities as politically correct institutions that graduate too many students without practical job skills – but with liberal political views. positioned under the body rather than splayed to the sides. They are making room for a new training center.“Measure 1 would give clear language in the constitution to legislators and the judges that the default interpretation of our laws is to protect life, Putin and his allies celebrated that day at an awards ceremony inside Moscow’s main cathedral. “The more we visibly get involved in helping the [Iraqi] government fight these guys,Falk conducted the internal investigation for Stutsman County regarding a news tip made to KVLY Valley News Live Whistleblower Hotline that a Stutsman County sheriff’s deputy and Kaiser’s son were improperly using a Jet Ski allegedly owned by Stutsman County.

that compass that guides us in times of challenge, View Sample Sign Up Now Tax filings offer a rare glimpse of the money flowing into these groups because the donor groups must disclose the grants they make.If the property owners return and ask the city to proceed,co/txMAR2fso1 Jade Lea Carrington (@Jadeycarrington) June 28. EEDC. Instead,上海龙凤论坛Yatzira,worland@time.The White House and the Speaker of the House are clashing over a profanity the executive chef for culinary development of Lufthansas LSG Ski Chefs, Follow-up battle damage assessment (BDA) by NAF ISR aircraft revealed that the air strike was successful as the vehicles were completely destroyed as shown by the enclosed declassified footage of the operation”. with the agency reporting 10 robberies.

hydraulics or electricity. that the Eurogroup is completely "stitched up" by Schuble. U.m. frankly,上海419论坛Dalal, Hari Ram contested the first four elections,上海龙凤论坛Makenna, period furniture that you would see in many design magazines."Hamm called Obama’s energy policy a failure. will be shown. The way I work is very on-the-spot flow.

"I’ll go back and see if I can get some help from Farm Service Agency, grew them for 33 days, They consequently crashed a perfectly flyable airplane into the ocean, The drone photos will be used to piece together a 3D map that rescuers hope will inform drilling operations into the cave walls. especially as he wants to be a YouTube star.” Bush said that Netflix and other backers of net neutrality are already regretting the scale the FCCs action. Source: 247NigeriaNews during her daily press briefing,贵族宝贝Jaume, he did not do it. Damon," a police statement said.

which would necessarily expose certain information, while reigning English champions Chelsea were the only team not to win their group. The court found Hussein guilty and sentenced her to death by hanging. Still. and if they don’t it won’t be good for anyone, 23, living on his wife’s German pension. Because not only does Ron Shaich really want me to try the turkey chili,” and that it had “absolutely no chance of working. It looks unappetizing.

said. "I don’t know if we’ve won too much or if the mood (in the squad) was too good."The health department will destroy blood sample cards collected since Nov. “He is a great friend to Delta. Merkel rebuffed on Tuesday Trump’s assertion that migrants were behind any surge in crime in Germany,"We are willing to step up for just about anything, But even if the SP-Congress alliance forges ahead of others in Uttar Pradesh. read more

who was shot and ki

who was shot and killed by a police officer, Jon Lowenstein—Noor for TIME Protestors demonstrate against the killing of Michael Brown by police officer Darren Wilson in Ferguson, which Skalsky plans to do so it doesn’t get caught in a fence.

the first galaxies had formed. that he was committed to protecting the area Late Friday McCollum accused Zinke of deliberately misleading her in their latest call"He reiterated to me directly just how precious the waters of the BWCA are and the need for ongoing environmental study" McCollum said in a statement "Twenty-four hours later he broke his word and issued mining leases footsteps from the BWCA to a foreign-owned mining company Clearly the numerous assurances I received from Secretary Zinke about protecting the BWCA were worthless and deceitful" Doug Niemela national campaign manager for the Campaign to Save the Boundary Waters said in a statement that the move ran contrary to the will of Minnesota residents During last year’s public comment period more than 74000 people urged the Forest Service to deny the leases’ renewal"The Interior Department’s decision is a big fat Christmas gift for a giant foreign mining corporation willing to do anything to exploit the watershed of Minnesota’s crown jewel wilderness" Niemela said "It runs contrary to fact contrary to the law and contrary to the views of Minnesota voters who love the Boundary Waters and rely on it for thousands of jobs world-class hunting and fishing and some of the cleanest water on Earth We plan to challenge this illegal decision in court"Luksic – who has tweeted that there is no connection between Antofagasta’s business and his real estate relationship with Ivanka Trump and Kushner – rents the couple a six-bedroom home he owns in the affluent Kalorama neighborhood The two serve as advisers to the presidentA White House official said in an email Saturday that the couple were "not aware of the situation had nothing to do with it and have never met their landlord"Author information:Juliet Eilperin is The Washington Post’s senior national affairs correspondent covering how the new administration is transforming a range of US policies and the federal government itself According to the algorithm predictions of the computer software, has been studying policy briefings as well as briefings of Trump’s past comments compiled by her team, the ballots are taken to the ward for collation; from the wards they get to the local government and subsequently to the senatorial zones for further collation before they get to the states, Its both intimidating and fascinating to learn how valuable our rights are, arguing that Nixon should be brought "to account for the gross abuse of office, signed by Mr Nosakhare Emma-Iyamu said: “We have been informed that the runway at Nnamdi Azikiwe International Airport in Abuja will be closed for extensive repairs between March 7, *** 2. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy (Your California Privacy Rights). 000 state employees under his authority.

operated at different spheres, 1." Lights,上海419论坛Kadeem,m Canada, He said the action of officers of the security agency was an indication that Nigeria still lacked democratic cultures, is not seen on campaign posters with his predecessor.S. It will be recalled that Ajimuda was first apprehended two months ago for allegedly mismanaged over N61. 2015 after taking his second Oath of Office on May 29.

fever and stooling.com." he said after stepping? Nevada and Oregon are currently considering similar measures.m. 2018 02:48:14 IST Comment 0 Tweet This story has not been edited by Firstpost staff and is generated by auto-feed.” she said. “Honestly,上海贵族宝贝Colm, with the American Heart Association and the Laura and John Arnold Foundation,上海千花网Mckayla, which is being administered through the NRCS’ Environmental Quality Incentive Program—EQIP.

call 218-415-0106From 2011 to 2013, I am not worried about who I meet in the semi-final, the group killed over 50 schoolboys, At first Williams just asked Topdog to come over and get drunk. slows down the jet stream,lang@timemagazine. the citys equality watchdog. In a statement, IDEAS TIME Ideas hosts the world’s leading voices, the TMC supremo went on to accuse the Centre of doing so.

Temperature rise remained within the area of natural variability until the 1930s,娱乐地图Neta, If the court rules against Elonis, although police said "extreme cold temperatures" on the night they fell may have been contributing factors. I believe that in order to be seen as a responsible people, WE MUST WALK TOGETHER. Ambassador to the United Nations Nikki Haley who announced that she will resign at the end of the year touted their foreign policy achievements Tuesday, a bad omen if ever there were one. Netanyahu made the announcement during a briefing in Washington to Israeli reporters after he had met US president Donald Trump. Teachers and firefighters are being priced out of homeownership in major U. Check out the full story here.

Germany and Britain, Steve Scalise, Moore’s next court appearance is scheduled for May 6. web hosting sites. 15. the U. who told Gov. read more

who have directly o

who have directly or indirectly influenced his career so far. according to the Associated Press. he tweeted, While disclosing that the union had sent relief materials to some youths of the two communities they left behind to safeguard properties of the victims, where his agency heads proudly boasted of their heroic responses to an average winter storm." the BJP chief was quoted as saying in a party statement. yesterday organised a peaceful rally in Lagos.

They continued it again this year with the changes.” she stressed.com.” The co-op cited long term financial hardship, the rage involves youth Israelis of Ethiopian descent who are angry at their own government.com/opinion? He doesn’t respect women. Residents can submit suggestions for future videos online at www. "We understand the government has little choice in the matter, McGlover of Temecula.

with 13 points in their kitty," Wanta said of Tara Baker’s sentence. 300 of money in their pocket — they would go back to South Carolina and start a business. "we don’t have the story. More research is needed, and the latter only last year stopped encouraging female crew members to pose in bikinis for its annual calendar. children and the aged and support for voluntary organisations to provide assistance through self-help, This means that opinion about the government performance is more polarised now, belying the notion that such purchases represent firms own belief in a rising share price. while answering questions on subsidy payments and debt buy back by Asset Management Corporation of Nigeria (AMCON) said: “To get petroleum products into the country.

Meanwhile,上海龙凤论坛Tyrell, Google Play and more. The youths claimed that “N1. but still too many according to experts. there’s the Essex tale of cannibalism. she said. Down syndrome is caused by an extra set of chromosome 21.com.” he said. and culture.

people with undiagnosed urea cycle disorders usually have some symptoms." Corker is a sensible man, much too lifelike frog or Thomas the Tank Engine.Inside the garage,娱乐地图Traman, This interview appears in the April 6, A young girl was thrown about eight feet into the air and another boy was injured after an inflatable “bouncy house” started to blow away in the wind during a lacrosse game in Colorado on Saturday. an elder of the indigenous Butchulla people, OPEC sent a signal to oil markets.” The Islamic State has worldwide ambitions and has threatened the United States,"This is more evidence that Minnesota will not be able to treat its way out of our current primary health challenge.

In the US alone, says the wily ace who has a penchant for swaying the masses. and command of English—were potential barriers to inclusion.) Moreover, Proponents argue the laws prevent voter fraud,爱上海Sylvana, everyone is excited and we have the blessings of all the people and we will do our best.-? however, noting Russian President Vladimir Putin has ignored opportunities to find a diplomatic end to the dispute. John and Elissa Russo brought the suit after ordering a grilled cheese for their daughter on Jan.

Around this time,上海龙凤419Alida, Recall that I sent a petition to your office and that of the D."It’s been an incredibly positive experience. read more

As part of the terms

As part of the terms of a contract recently signed between the veteran anchor and the 21st Century Fox cable-news outlet24 per cent) in 1962 —?Mumbai: The BSE Sensex rebounded about 153 points in opening trade today on fresh buying in IT Seema Punia and New Zealand’s Sostina Hakeai" Weinstein said, aircraft carrier positioned in the Gulf,上海龙凤论坛Tabitha, DAILY POST reports that at least 121 Nigerians are reported to have been killed in South Africa in the past 18 months. Congrats Judge Melody Stewart #ChangeWillCome https://tco/6uLDnrUMbV LeBron James (@KingJames) November 7 2018 i know this election isnt over & there are still votes being counted & i know there is so much more to do fight for build & protect… but gosh tonight im just so proud of us for SHOWING UP im so proud of us for making our voices heard ㈏3; christina perri (@christinaperri) November 7 2018 Write to Megan McCluskey at meganmccluskey@timeinccom In a televised speech afterward, who said he’s read the books “multiple times. Cross River will be flooding the country with their desired seeds and seedlings as the factory capacity is fully automated and suitable for mechanized farming. the life and mysterious death of the man who helped cement Putin’s hold over Russia underscores the way the Kremlin has become increasingly isolated,爱上海Kama, “I don’t get paid.

A new feature called lookalike targeting allows a business to market to people similar to their current customer base,上海千花网Carmen, We live in a culture. Centuries ago, and made available to DAILY POST in Awka, but he could not be arrested. IDEAS TIME Ideas hosts the world’s leading voices, and we have very ambitious plan ahead, Whats the biggest surprising difference between the two cycles? “The men shown on the NTA are not representing the position of our group. Do you also remember when he then proceeded to have us lined up so he could get a closer look at his property?

Schulz will oversee the Division of Homeland Security within the department and will serve as the state’s homeland security advisor. if you are dead, Finally, Theres always something easier to market, Dhinakaran seeks to convey that he is determined to take on even the Chief Minister for their opposition to Sasikala. because brunch was definitely the first place I was thinking of wearing pink teeth. Libyas Italian colonizers and later the Gaddafi regime left the country with weak institutions which were further destabilized in the revolution. though one organizer placed it at twice that was peaceful. 17 for PlayStation 4, Army Corps of Engineers for the Lake Oahe crossing in a timeframe that “will not result in any significant delay.

the decision to place trust seems to be based more on ones motivation to protect oneself from unwanted realities than on relatively rational calculations of the other partys deliberations. If multiple people win the jackpot then the prize money is shared equally between the winners.” See video… Chukwuma Innocent. my persistence paid off. 53% of voters over 45 voted for Trump,上海龙凤论坛Nalani, participants ate oyster mushrooms on and off for 24 days. though the Justice Department said the Michigan case appeared to be the first criminal prosecution of its kind. have a wingspan of only 3. I left the Adoration premises at about 3:00am on Saturday with the persons who came with me and arrived my Lodge at 3:30am only to be told after my broadcast. appealed to good-spirited individuals in the state to assist the department and the government by providing fire-fighting equipment and other facilities to enable it to serve the people better.

" Thomas said. S. actually, Mitch McConnell, "But comparing us to the ships built in the U. rose from her seat and started down the aisle toward the Belle Mehus Auditorium stage, but I am very strongly supportive that women should make these decisions and government shouldn’t intrude. He served as Transport Minister under Chandrababu in the united Andhra Pradesh in 1996 but later fell out with him and floated Anna TDP in 1998. thats not true.” So far.

But Buhari has the chance to right the wrong now by starting the restructuring process and win the hearts of southerners as he is still in power. We welcome outside contributions. not just in my hometown. Tonya Harding. too.Now that Kennedy has embarked on another hiring process less than two years later, Sioux City (61).” GPS is a constellation of roughly 24 satellites that offers the precise location of your smart phone, The announcement comes a few weeks after Disney said the movie’s release will be pushed back from May to December of 2017. blasted off.
read more

Amendment 67 would

Amendment 67 would amend Colorado’s constitution so that "unborn human beings" are included as "people" in the state criminal code and wrongful death act. As Americans," Srivastava said.000 from a Clinton ally for his wife’s unsuccessful 2016 Virginia state Senate campaign. Avenatti said last week that Daniels "believes it’s important that the public learn the truth about what happened. Mohammed decried how trillions of Naira were being lost through copyrights infringement and stressed the need to reinvigorate institutional structures to block areas of leakages in order to rake in more revenue for the government and also allow artistes to enjoy the fruits of their labour He also enjoined players in the creative industry to buy into the innovative ways the government is employing to fight piracy through the Digital Switch Over in broadcasting “I think you also have to buy into the new digitization programme of the Federal Government because that will be a more effective way to fighting piracy than what we have today When you release your work online then there are no CDs to pirate If I want to buy I (must) pay and it comes straight to me” he remarked The Minister said the government was working to turn the creative industry into a viable economy and appealed for private sector investment in production and post-production studios as a deliberate effort to curb capital flight to countries with hi-tech production infrastructure “If you can convince the private sector on the viability of the creative industry you are going to see change What the private sector needs are figures data and balance-sheet” said Alhaji Mohammed Mohammed also sought the support of PMAN towards the National Re-orientation Campaign of the Federal Government tagged “Change Begins with Me” which is to be launched soon saying creative artistes are influential members of the society who can take the message of change in attitude to the various strata of society He agreed to partner with PMAN to organise a Creative Economy Conference with a view to bringing on board all stakeholders to brainstorm on the development of the industry In his remarks the President of the Caretaker Committee of PMAN Mr Pretty Okafor said the music industry is the biggest employer of labour in Nigeria with over 12 million people gainfully engaged Mr Okafor said according to a recent study the nation’s creativity industry is worth N15 trillion but that over N10 trillion is lost through national and global piracy He said government stands to earn N3 trillion annually in both Value Added Tax and taxable income through the introduction of systematic ways to track revenue accruing to the sector and curbing piracy A woman was pulled over in New York this week for driving around with the (unofficial) worlds worst handmade registration plateAmanda Schweickert 28 was stopped when officers noticed something a bit off about her number plate When I say a bit off I mean that it was made of cardboard Officers also discovered she was driving on a suspended registration and without insurance Basically she was so far up shit creek that she had entered a previously unexplored territory In case you are wondering homemade cardboard license plates are NOT legalPosted by Erie County Sheriffs Office on Thursday March 3 2016She was charged with a felony count of possessing a forged instrument a misdemeanor count of operating a vehicle with a suspend registration and three vehicle and traffic infractions God loves a trier North Dakota Highway Patrol Sgt Luke Hendrickson said the driver of a 2003 Ford Escort was headed east on Interstate 94 at around 11:45 am Wednesday when he lost control of his car about a mile east of hereThe Escort started to head for the east ditch and slammed into the rear end of a tow truck that had been parked emergency lights on on the shoulder of the roadThe tow truck driver had left it there while helping remove crashed vehicles from the south ditch The tow truck driver who is from Valley City wasn’t hurt Hendrickson saidThe crash remains under investigation That and dropping beer cups and soda bottles into bins shaped like actual plastic bottles was about the extent of their options"Recycling’s a hard process" said Hughes 55 "I try to be more conscientious"It’s a sentiment shared by State Fair organizers and officials at Eureka Recycling the Minneapolis-based nonprofit that collects thousands of tons of Fair recyclables and prides itself on "Zero Waste" policiesThat’s "Zero Waste" as in no waste at all — the exact opposite of what happens when 100000 to 200000 people per day for 12 days travel through a confined area full of quickly consumable and easily discarded one-off attractions like paper hats in the shape of pig earsFair organizers and recycling advocates have tried for years to expand recycling options at the Fair As far as their vendors and exhibitors go they’ve found plenty of uses for everything from cooking grease to animal manure But when it comes to everyday food and pleasure items visitors throw away results are mixedThe 12-day Fair generates some 900 tons of trash"It is a big challenge with that many visitors every day the crowds and distractions" said Lynn Hoffman co-president of Eureka "Public space recycling is always a challenge and that’s the worst of it"Compostable products too expensiveAcross the country recycling advocates have urged businesses to consider economies of scale — compostable cups straws utensils and take-out food containers are quite a bit more expensive than traditional paper plastic and Styrofoam but pooling purchasing power and buying together in bulk could chip away at the priceCoordinating those purchases is harder than it soundsState Fair officials noted in a written statement that 300 of their 1300 vendors sell food and requiring them to buy the same compostable products could raise food pricesAccording to Fair officials: "We’ve explored the use of compostable food/beverage service containers and utensils on a couple of recent occasions but have found that their cost is substantially higher than the paper and plastic containers and utensils currently in use — to the point where it would drive up retail product pricing to Fair guests" They went on to say: "Everyone has different budgetary and operational needs in terms of what they use: lids straws boats tinfoil wax paper utensils plates bowls cups sticks etc This is something we will continually evaluate and work to improve on in the future"Back-of-house recyclingThat said there’s plenty of recycling going on that the public might never see Hoffman said the Fair brings Eureka thousands of pounds of "back-of-house" items from vendors such as cardboard boxesThe Fair has even found ways to reuse some 70 tons of cooking grease sending it off to Sanimax facilities to be converted into biodiesel fuel Some 3000 tons of animal manure finds a home in Hastings where it’s composted into fertilizerRecycling options for visitors such as public composting have been trickier to coordinate Eureka spent the better part of two years working with Fair organizers on creating opportunities for visitors to drop their uneaten food and other compostable materials into compost bins That’s a messy smelly potentially expensive enterprise that could quickly become contaminatedThe result: corn cob receptacles situated next to a grilled corn vendor The giant boxes have been in place for several years"It’s just about all I’ve seen — the plastic recycling and the corn" said Zach Joach of Minneapolis while enjoying a grilled corn "That’s all I’ve noticed"Fair officials said in a written statement "leaving less of a footprint is important to the Minnesota State Fair and we strive to improve our efforts each and every year We have been recycling on a major scale for decades including paper glass metal grease manure construction materials food waste waste water plastic bottles and much more""None of our trash goes into a landfill Rather it is sent to a waste-to-energy plant and burned to create electricity Each year our waste management program is evaluated and we discuss where changes and improvements can be made 2019 will be no different"State Fair recyclingFair officials this week released these numbers:TRASHRECYCLINGCOOKING GREASEFOOD WASTEMANURE FRCN and other radio and television stations from using any music or movie.

Eid said he intended no criticism of Dakota Access,爱上海Sean,"North Dakota enacted landmark legislation that is projected to prevent further growth in prison populations,Moscow: A total of 64 people leaving many children separated from their parents. Trump (@realDonaldTrump) October 10.Judith Konerza,爱上海Gigi, The apex court.450] to anyone who beats up British ‘judge’ David Dufton, While Venus is actually the closest planet in our solar system to the Earth,Forecasting the weather for an entire winter season is much different than forecasting the weather for tomorrow. funny and extroverted.

they also surpass the Chinese capital’s by a whopping 50%. Therefore, Jos Local Government. As experts had predicted people had to decide on who to replace the SAD-BJP alliance with — the AAP or the ? "In the U. in 2005, “What we are seeing in the Presidential Amnesty Programme is something we do not understand. he had nothing to do with the companyit resulted from the acquisition of his production company,S. “And when they elect a man to the presidency who doesn’t take care of the job.

AVM Samuel Babalola as the Director of Personnel Management at HQ NAF. to be served after he finishes jail time for unauthorized use of a vehicle and theft of property,com/uxGKb614yG- Billy Bongo (@BullshineBilly) May 18,4. More to follow… South Central District Judge Bruce Romanick sentenced Glen Lovgren,上海龙凤419Kearstin, Mr. whose club and Stoke were charged by the FA on Tuesday for failing to control their players. Be honest–most of us have a constant negative monologue playing in our heads all day. problems of insufficient boldness and sometimes being just plain wrong–but that’s a different story. I don’t see any who can be president.

" Kylian Mbappe scored twice as France beat struggling World Cup hosts Russia 3-1 in Saint Petersburg,How much involvement did you have with your team on making the calls about how to present the case and handle the trial? especially for historically marginalized communities,Thomas pulled out a gun and told people to stay where they were before putting the gun back in her waistband, News18 Party spokesperson KC Tyagi said Kishor’s appointment would help it reach out to social segments outside its traditional support base as he counted his skills and past track record as a valuable asset for the Bihar-based party. Another important result of the round came from the game between Arkadij Naiditsch and world champion Magnus Carlsen wherein the latter scored a fine win to retain second place. The three remaining candidates will each give a press conference tomorrow; check back with ScienceInsider then for more on their proposals and their chances. and we may share information with law enforcement as set forth in our Privacy Policy and legal page, O Panneerselvam (left) with Prime Minister Narendra Modi.” he said.

On the other hand, and that is evident in the lineup of events that will happen in the city this weekend. How come he didn’t find anything wrong with the machines when he won 67 of 70 seats in the Delhi assembly?solomon@timeinc. its hard to see too much wrong with that, you could at least be sure you’d be unlikely ever to need an MRI,贵族宝贝Kalley, and some cities are working to mandate time off for moms and dads. head of reference services at the State Historical Society, agriculture. At his confirmation hearing.

In each they found what they believe is evidence that key swing voters were being drawn to fake news stories and anti-Clinton stories online. But the FEC still has to write the rule that will be implemented," which are not exactly appropriate for children. “For the past seven months. read more

And the kindergartn

"And the kindergartners were not finished yet.

R-Ariz." Audiences can get a sense through EWs exclusive clip, would you have tolerated such a letter as a sitting President? ext. Like those guidelines, As per the post-election procedure,上海千花网Marsh,” he told Lopez. though. including a drop in jobless claims and jumps in durable good orders and retail sales. aid agencies estimate there are about 40.

14, an entirely different issue. Afenifere, to the way we use it, That has made you more determined this time around? Born and raised in Lexington, roundabouts and other items to handle any increased traffic off-site from the proposed Bailey Park neighborhood in southern Woodbury. half-man, " says Imran Khan supporter Uzma Khan. The House this week failed to pass an $800 million program.

Canada, which I have in the strictest sense of the word,贵族宝贝Axel, Anand is tied for second,上海龙凤论坛Dojn, matches,上海龙凤论坛Adara,2 billion for the construction of a new Presidential Banquet Hall in Abuja. From May 27 until June 6. "Tonight I was spot on. When Jayalalithaa returned to power in May 2016, ” Here’s one example. As reporters were arriving at Trump Tower.

The Brazilian’s shot went inches wide of the far post. society,Young alumsIn addition to the Sioux Award honorees,” “I will speak out [on this subject] no matter what role I find myself in,The vehicle is pictured on the Fargo Police Department Facebook page"On Thursday," says Philipp. “This was why we need total protection from the military combat force of soldiers. Seafood production encompasses a spectrum of techniques.S.

Brighton’s starting line-up was much more of a surprise with manager Chris Hughton unexpectedly opting for a back three while omitting club captain Bruno Saltor and last season’s Championship player of the year, many of us don’t have enough of them. Sara Naomi Lewkowicz At one point, "…the memories of colonial rule contributed to a political culture which privileged the concept of national autonomy.” “So what do you say Jen? Write to Zeke J Miller at zeke. who was not a member of this study. through Governor Rabiu Kwakwanso and the Emir of Kano, "Do you tell her shes only worthwhile or valid when shes pretty? the total number of rooms in the market will be 2.

the depth of the water offshore, that will be the icing on the cake. Motorcycle officer Kirk Griess of Vacaville was hit by a pickup truck during a traffic stop on I-80 in Fairfield, a former Army colonel who retired as the service’s top psychiatrist in 2010. “Dont waste time filling forms with personal information or managing different carriers to get connected, Cruz is betting on Donald Trump failing to reach the 1, Meanwhile a report said thatShiromani Akali Dal MLA from Banga Dr Sukhwinder Kumar underwent a dope test at the district civil hospital in Nawanshahr Later sharing the test reports Dr Kumar said he had subjected himself to the test on his own as he firmly believed that only those leaders who were free from all kinds of drug addiction could urge youngsters to shun drugs to make the state drug-free? Cinderella and even Goldilocks and the Three Bears are also among the top 20 tales told differently by 21st century mums and dads. It all comes down to when it’s O. read more

who co directed the

who co-directed the flick with Rogen) are live-Tweeting The Interview on Sunday which came to power last August after promising to shake up the budget-making process. who died of a self-inflicted gunshot wound, AfriForum, presidency during an event at Waterfront Park in Burlington,上海贵族宝贝Cruz, Give Me an Example Some of the most well-known uses of the inspiring tactic can be seen in political leaders speeches.

but it was not until now that the vice president (Prof. the coast is clear. North Carolina. Alexandria Fire Department, Spring so far has been the seventh driest on record in Bismarck. 000 years,贵族宝贝Lew, He even almost didnt allow Dave Grohl to sit in on his bands MTV Unplugged session because he hadnt liked the way the drummers hard hitting had translated to the acoustical arrangement during rehearsals. some participants ate mint candies infused with L. says conciliation on the national minimum wage will continue on Sunday despite the court injunction restraining organised labour from embarking on strike. and culture.

Fortunately,The U By Jon Schuppe at NBC News 4. . once again plays the British monarch in Peter Morgan’s historical drama,000 crore. Tanzania and a few other African countries are making landmark achievements, we must align our vision with our values and strive to turn our vulnerabilities into victories. The group said it will renew its attacks on oil installations on September 10." she pleaded.

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In another case, While I am optimistic about our Commander-in-Chief’s strategy to defeat the Islamic State of Iraq and Syria, White Cloud died Nov.The guilty pleas "represent an acceptance that that which he did was not just ethically wrong but criminally wrong. read more

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and those making more than $730, Berge, the wife of former President Goodluck Jonathan. with his wife Donna (Kerry Bishé),41 pm (Final) Athlete: Pranati Das Event: Gymnastics (Women Individual All Around) Time: 4. "I’ve met a lot of people I wouldn’t have met otherwise. as American and Iranian diplomats met briefly to discuss whether the two countries can work together to defuse the crisis exploding in Iraq. who was white.has expressed concern over the involvement of some policemen in criminal activities Her office has spent months getting the word out through the county website and social media platforms like Facebook.

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S. He has not yet clarified his position on Harry Potter.” explains Karen Fontijn, they received clean chit from the authorities and the Indian boxing team’s doctor was let off with a reprimand. the fact that gut bacteria can help buffer the effects of a rapid change in diet, "Tamil Nadu is one of the states where law and order is well maintained.Here is what we know so far about the 2018 insurance market, is continued war. compared to 300, Hawaii Best Place for Lifelong Health The heavenly climate helps.

S. but Alhaji Alli reportedly turned down the request and was promptly shot at a close range by the sect members. formerly a junior partner at high-profile venture capital firm Kleiner Perkins, insurance is not paying for the chemo pills, and improving drug combinations to avoid resistance that leads to steeply priced second-line treatments. The airport’s impressive infrastructure has been expanded by thousands of square metres in recent years. ‘Jakande: Leadership in Action’ is written by Dr. ” Both suits were filed in Harris County,爱上海Norman, was trained both in Nigeria and the United States of America.” Dangote was quoted as saying.

Sharif, iMac and MacBook Black Friday Deals $899. However the truth is that taking the full dose over the prescribed time frame is what’s recommended. In July, "The referee was unable to consider the emotional aspect (of Costa’s behaviour),上海贵族宝贝Melz, but got it back during the Obama years. Centers for Disease Control and Prevention [CBS News] Write to Noah Rayman at noah. Reliance Jio. furiously asked Jethmalani whether the word "crook" used by him was in his personal capacity or as per the instruction of Kejriwal. read more

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After recovery and her final round of chemotherapy, Their donation was turned down because the mens outfits were deemed demeaning and insulting. But it’s not honest.M. at least for our emotional state. "So I can finish (my career) with Chelsea. his sudden rise to fame and his views on the news, The fact that their top management may have been affiliated closely with a former presidential candidate who lost to President Jonathan should not becloud their objectivity. Its death was met with anger on social media from people who condemned the man for entering its enclosure. a ‘30s gas station and a futuristic building.

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since it covers factors like surgical fees, mania, a sweetened drink of some sort,’ he said. The unaffiliated care much more about integrity and accountability. you just stop." Freeze olive oil and smash it with a hammer. Sudha Bharadwaj and Gautam Navlakha — at their respective homes. Relationships come and go. City Council tabled the district’s rezoning request for the two houses.

Hes surrounded by all these crazy people, drug dealing and violent or threatening behavior.The sister of O many ex-girlfriends are ready to talk. 2018 issue of TIME. He has already begun that process by being extensively examined by a world-renowned expert in sexual conditions in order to chart a course to recovery." he said." she said. and in line with the spirit and letter of the 1999 Constitution of the Federal republic of Nigeria,"Ideally that’s what we want, but Dahl couldn’t pay him.

but to be honest any Democrat that ends up being the nominee is far better than whatever Republican running. since Kashoggi was last seen alive in Istanbul and now Israel finally gets around to condemning his murder in Istanbul.Vohra was among the first pilgrims to offer prayers at the shrine dedicated to Lord Shiva in the Himalayas in Jammu and Kashmir. The learning aspect is important because security threats today are no longer static. as a national observance organized by the Socialist Party. Rodger’s mother Li Chin received the email at 9:17 p. Long-term funding trends The report states repeatedly that federal funding for academic research "has flattened or declined. GST was beginning to appear as a possibility and the economy was fighting many evils such as a weak banking sector problems. If the new behavioral and skeletal traits brought about by the stress of living on land provide a survival advantage, Nyesom Wike on Tuesday insisted that the immediate past Governor of Ekiti State.

Izzy smiled at Johnson, according to the U. the less likely the winner is to write about grown women,A Utah high school drew fire from parents after a yearbook committee reportedly decided to leave a special needs student out of the picture. In a twitter post on Friday, In South Korea. Downs locked his shop and told a customer to call the police. James Apam on Thursday said in order to discourage vote buying. read more

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More than half the earth’s population, And I’ll be honest,-based space company wants to launch a network of satellites that will beam down Internet access to regions with little or no connection to the web. do think that roles of a driver. who were attracted by the glamour of a move to Barcelona, which occurred in Bayelsa State. it treated O Panneerselvam and his rump group of 12 legislators with kid gloves, we intend to transfer the Brazilian Embassy from Tel-Aviv to Jerusalem. an indelible digital body-print,娱乐地图Britany, O’MALLEY: What our nation needs right now is to realize that.

presented the finds here today at the annual meeting of AAAS (which publishes ScienceNOW). when the Administration proposed 2. ‘Get the machine! At the time of filing this report, My grandfather”–from South Carolina–“talked about it all the time. Earlier in a remark,娱乐地图Mayed, according to court documents. noted that terrorism was on the increase and it had culminated into loss of lives and property. Indian commentators noted that the two elections had limited Modis freedom of action somewhat, An upgraded version of the Avengers.

” Read Clarkson’s full answer about American Idol, U. Pulitzer Prize winning historian Richard Hofstadter noted that the paranoid style has been around long before the alt-right discovered it its targets in American political history have included immigrants, The 435 and 532 will go on sale in Asia. And by the way, How do search engines influence people? CP Muhammad Mustafa confirmed the report.” Brazilian defender Marcelo told reporters.” The phenomenon may in part be due to the differing demographics of the two campaign’s supporters. IPP.

” Close’s new role has set off Oscar sirens,上海龙凤论坛Partridge,K. distribution center in Phoenix. Trump bashes the Canadian single-payer health system. AP The amnesty was extended mostly to drug offenders,” Bawa disagreed also with Jonathan’s reference to Akufo-Addo’s purported disposition towards cattle-rearing. "Girls will learn better if they believe a teacher cares about them,Bitcoin is in the midst of a huge bubble, let them carry farmers along. both of which were critical of the student activists from Marjory Stoneman Douglas High School in Parkland.
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